ArticleJournal of the International Society of Sports Nutrition2012
β-alanine supplementation improves isometric endurance of the knee extensor muscles.
Article in Journal of the International Society of Sports Nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Dosing strategies for β-alanine supplementation in strength and power performance: a systematic review.Journal of the International Society of Sports Nutrition · 2025Pooled it
- Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis.Journal of the International Society of Sports Nutrition · 2022Pooled it
- Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial.Journal of the International Society of Sports Nutrition · 2026Trial
- Comparative effects of caffeine, beta-alanine, and their combination on mechanical, physiological, and perceptual responses to upper-body superset resistance training.European journal of applied physiology · 2025Trial
- β-alanine supplementation improves in-vivo fresh and fatigued skeletal muscle relaxation speed.European journal of applied physiology · 2017Trial
- Acute Effects of a Multi-Ingredient Preworkout Supplement on Peak Torque and Muscle Excitation During an Isokinetic Fatigue Protocol.Sports (Basel, Switzerland) · 2025Article
- Does beta-alanine supplementation enhance adaptations to resistance training? A randomized, placebo-controlled, double-blind study.Biology of sport · 2023Article
- Beta-alanine Supplementation for Four Weeks Increases Volume Index and Reduces Perceived Effort of Resistance-trained Men: A Pilot Study.International journal of exercise science · 2021Article
- A Pilot Study to Examine the Impact of Beta-Alanine Supplementation on Anaerobic Exercise Performance in Collegiate Rugby Athletes.Sports (Basel, Switzerland) · 2019Article
- Timing of ergogenic aids and micronutrients on muscle and exercise performance.Journal of the International Society of Sports Nutrition · 2019Review
- The effects of 10 weeks of β-alanine supplementation on peak power, power drop, and lactate response in Korean national team boxers.Journal of exercise rehabilitation · 2018Article
- International society of sports nutrition position stand: Beta-Alanine.Journal of the International Society of Sports Nutrition · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe examined the effect of four weeks of β-alanine supplementation on isometric endurance of the knee extensors at 45% maximal voluntary isometric contraction (MVIC).
methodsThirteen males (age 23 ± 6 y; height 1.80 ± 0.05 m; body mass 81.0 ± 10.5 kg), matched for pre-supplementation isometric endurance, were allocated to either a placebo (n = 6) or β-alanine (n = 7; 6.4 g·d-1 over 4 weeks) supplementation group. Participants completed an isometric knee extension test (IKET) to fatigue, at an intensity of 45% MVIC, before and after supplementation. In addition, two habituation tests were completed in the week prior to the pre-supplementation test and a further practice test was completed in the week prior to the post-supplementation test. MVIC force, IKET hold-time, and impulse generated were recorded.
resultsIKET hold-time increased by 9.7 ± 9.4 s (13.2%) and impulse by 3.7 ± 1.3 kN·s-1 (13.9%) following β-alanine supplementation. These changes were significantly greater than those in the placebo group (IKET: t(11) = 2.9, p ≤0.05; impulse: t(11) = 3.1, p ≤ 0.05). There were no significant changes in MVIC force in either group.
conclusionFour weeks of β-alanine supplementation at 6.4 g·d-1 improved endurance capacity of the knee extensors at 45% MVIC, which most likely results from improved pH regulation within the muscle cell as a result of elevated muscle carnosine levels.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.