ArticleCutaneous and ocular toxicology2013
The effect of physiologic aqueous solutions on the perovskite material lead-lanthanum-zirconium titanate (PLZT): potential retinotoxicity.
Article in Cutaneous and ocular toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 17 citations in OpenAlex.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
contextPerovskite compounds, including lead-lanthanum-zirconium titanate (PLZT), have wide technological application because of their unique physical properties. The use of PLZT in neuro-prosthetic systems, such as retinal implants, has been discussed in a number of publications. Since inorganic lead is a retinotoxic compound that produces retinal degeneration, the long-term stability of PLZT in aqueous biological solutions must be determined.
objectiveWe evaluated the stability and effects of prolonged immersion of a PLZT-coated crystal in a buffered balanced salt solution. MATERIALS AND
methodsScanning Electron Microscopy and Electron Dispersive Spectroscopy (EDS) using a JEOL JSM 5410 microscope equipped with EDS were utilized to evaluate the samples before and after prolonged immersion.
resultsWe found that lead and other constituents of PLZT leached into the surrounding aqueous medium. DISCUSSION: By comparing the unit cell of PLZT with that of CaTiO(3), which has been found to react with aqueous fluids, Lead is in the same site in PLZT as Ca is in CaTiO(3). It is thus reasonable that PLZT will react with aqueous solutions.
conclusionThe results suggest that PLZT must either be coated with a protective layer or is not appropriate for long-term in vivo or in vitro biological applications.
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