ArticleThe European journal of neuroscience2012
Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 35 citations in OpenAlex.
- Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions.eLife · 2026Article
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- A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells.Bioengineered · 2021Article
- Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones.Seizure · 2021Article
- Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices.Frontiers in neural circuits · 2021Article
- Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Role for Electrotonic Coupling Between Cortical Pyramidal Cells.Frontiers in computational neuroscience · 2019Article
- Hippocampal-Cortical Memory Trace Transfer and Reactivation Through Cell-Specific Stimulus and Spontaneous Background Noise.Frontiers in computational neuroscience · 2019Article
- Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons.The Journal of physiology · 2018Article
- Memory replay in balanced recurrent networks.PLoS computational biology · 2017Article
- Article
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Gap junction networks can generate both ripple-like and fast ripple-like oscillations.The European journal of neuroscience · 2014Article
- Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes.Frontiers in neural circuits · 2014Article
- Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study.The European journal of neuroscience · 2013Article
- Recruitment of oriens-lacunosum-moleculare interneurons during hippocampal ripples.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cholinergic plasticity of oscillating neuronal assemblies in mouse hippocampal slices.PloS one · 2013Article
- Large-scale modeling of epileptic seizures: scaling properties of two parallel neuronal network simulation algorithms.Computational and mathematical methods in medicine · 2013Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Evidence has been presented that CA1 pyramidal cells, during spontaneous in vitro sharp wave/ripple (SPW-R) complexes, generate somatic action potentials that originate in axons. 'Participating' (somatically firing) pyramidal cells fire (almost always) at most once during a particular SPW-R whereas non-participating cells virtually never fire during an SPW-R. Somatic spikelets were small or absent, while ripple-frequency EPSCs and IPSCs occurred during the SPW-R in pyramidal neurons. These experimental findings could be replicated with a network model in which electrical coupling was present between small pyramidal cell axonal branches. Here, we explore this model in more depth. Factors that influence somatic participation include: (i) the diameter of axonal branches that contain coupling sites to other axons, because firing in larger branches injects more current into the main axon, increasing antidromic firing probability; (ii) axonal K(+) currents and (iii) somatic hyperpolarization and shunting. We predict that portions of axons fire at high frequency during SPW-R, while somata fire much less. In the model, somatic firing can occur by occasional generation of full action potentials in proximal axonal branches, which are excited by high-frequency spikelets. When the network contains phasic synaptic inhibition, at the axonal gap junction site, gamma oscillations result, again with more frequent axonal firing than somatic firing. Combining the models, so as to generate gamma followed by sharp waves, leads to strong overlap between the population of cells firing during gamma and the population of cells firing during a subsequent sharp wave, as observed in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.