Evidence map›Paper›PMID 22697270›Full record

Trial reportOcular immunology and inflammation2012

Optic nerve head morphology and visual field function in patients with AIDS and without infectious retinitis.

Igor Kozak, Alka Ahuja, Sapna Gangaputra, Mark L Van Natta, Jennifer E Thorne, William R Freeman

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ocular immunology and inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000168 (Studies of Ocular Complications of AIDS), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000168 completednot on this map

Studies of Ocular Complications of AIDS (SOCA)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan1998 to 2013Enrolled2,392ConditionsHIV Infections, Acquired Immunodeficiency Syndrome, Cytomegalovirus Retinitis
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Igor KozakDepartment of Ophthalmology, University of California San Diego, Jacobs Retina Center at Shiley Eye Center, La Jolla, California 92037, USA. ikozak@eyecenter.ucsd.edu
Alka Ahuja
Sapna Gangaputra
Mark L Van Natta
Jennifer E Thorne
William R Freeman

Funding

Studies of Ocular Complications of AIDS - Coordinating CenterU10EY008057 · NEI · JOHNS HOPKINS UNIVERSITY · PI VAN NATTA, MARK L · 1988 to 2012
$78.0M
Studies of Ocular Complications of AIDS - Chairman's OfficeU10EY008052 · NEI · JOHNS HOPKINS UNIVERSITY · PI JABS, DOUGLAS A · 1988 to 2012
$8.0M
Studies of Ocular Complications of AIDS - Reading CenterU10EY008067 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI DANIS, RONALD · 1988 to 2012
$3.2M
NEI NIH HHS U10 EY008052NEI NIH HHS U10 EY008057NEI NIH HHS U10 EY008067NEI NIH HHS U10 EY 08052NEI NIH HHS U10 EY 08057NEI NIH HHS U10 EY 08067
6 · The paper itself

Abstract

purposeTo evaluate morphology of the optic nerve head and visual field in AIDS patients without retinitis.

methodsOne randomly selected eye from 246 patients with AIDS without retinitis was evaluated from prospective multicenter Longitudinal Studies of Ocular Complications of AIDS. Stereo fundus photographs of OHN and serial VF data over 5-years were analyzed. Main outcomes included vertical cup-to-disc ratio (CDR), mean deviation, and pattern standard deviation scores on VF testing.

resultsThe median CDR was 0.39 at enrollment and 0.40 at 5-year follow-up. An unadjusted linear regression model revealed a mean change in CDR of 0.004 after 5-years (P = 0.04). After adjustment for practice effect, there were no statistically significant changes in VF performance observed during the 5 years of follow-up.

conclusionsWe detected clinically minimal, but statistically significant changes in ONH morphology and no change in VF performance among eyes of patients with AIDS and without retinitis.

Indexed as

Visual FieldsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsCytomegalovirus RetinitisFemaleHumansLongitudinal StudiesMaleMiddle AgedOptic DiskVisual Field Tests

Identifiers

PMID22697270
PMCPMC4164231

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.