ArticleThe Journal of cell biology1990
The three-dimensional structure of the nemaline rod Z-band.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Klhl41b orchestrates sarcomere assembly and growth to drive skeletal muscle hypertrophy in vivo.Skeletal muscle · 2026Article
- The cryo-EM 3D image reconstruction of isolated Lethocerus indicus Z-discs.Journal of muscle research and cell motility · 2023Review
- Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth.PLoS genetics · 2022Article
- Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation.PLoS genetics · 2022Article
- Article
- Cryo-electron tomography of cardiac myofibrils reveals a 3D lattice spring within the Z-discs.Communications biology · 2020Article
- Update on Congenital Myopathies in Adulthood.International journal of molecular sciences · 2020Review
- Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle.Journal of molecular biology · 2015Article
- Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy.Journal of molecular and cellular cardiology · 2014Article
- Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.Brain : a journal of neurology · 2013Article
- Electron microscopy and x-ray diffraction evidence for two Z-band structural states.Biophysical journal · 2011Article
- The basketweave form of the Z-band is expanded relative to the small-square form.Journal of muscle research and cell motility · 2011Article
- Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).Journal of structural biology · 2010Article
- Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.Human molecular genetics · 2009Article
- The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling.Journal of muscle research and cell motility · 2009Review
- Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes.BMC cell biology · 2007Article
- Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo.The EMBO journal · 2006Article
- Alteration of tropomyosin function and folding by a nemaline myopathy-causing mutation.Biophysical journal · 2000Article
- Distinct families of Z-line targeting modules in the COOH-terminal region of nebulin.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In nemaline myopathy and some cardiac muscles, the Z-band becomes greatly enlarged and contains multiple layers of a zigzag structure similar to that seen in normal muscle. Because of the additional periodicity in the direction of the filament axis, these structures are particularly favorable for three-dimensional analysis since it becomes possible to average the data in all three dimensions and thus improve the reliability of the reconstruction. Individual views of the structure corresponding to tilted longitudinal and transverse sections were combined by matching the phases of common reflections. Examination of the tilted views strongly suggested that to the available resolution, the structure possesses fourfold screw symmetry along the actin filament axes. This symmetry could be used both in establishing the correct alignment for the combination of individual tilted views and to generate additional views not readily accessible in a single tilt series. The reconstruction shows actin filaments from one sarcomere surrounded by an array of four actin filaments with opposite polarity from the adjacent sacormere. The actin filaments show a right-handed twist and are connected by a structure that links adjacent filaments with the same polarity at the same axial level, then runs parallel to the filaments, and finally forms a link between two actin filaments whose polarity is opposite to that of the first pair. The connecting structure is probably composed of alpha-actinin which is located in Z-bands and cross-links actin filaments. The connecting structure may consist of two alpha-actinin molecules linking actin filaments of opposite polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.