ArticleProceedings. Biological sciences2012
Immune activation decreases sperm viability in both sexes and influences female sperm storage.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway.PLoS biology · 2025Article
- Review
- Semen adaptation to microbes in an insect.Evolution letters · 2024Article
- Fertility costs of cryptic viral infections in a model social insect.Scientific reports · 2022Article
- Pre-copulatory reproductive behaviours are preserved inProceedings. Biological sciences · 2022Article
- The developmental high wire: Balancing resource investment in immunity and reproduction.Ecology and evolution · 2022Article
- Trade-offs between sperm viability and immune protein expression in honey bee queens (Apis mellifera).Communications biology · 2021Article
- Interactions with ectoparasitic mites induce host metabolic and immune responses in flies at the expense of reproduction-associated factors.Parasitology · 2020Article
- Sperm success and immunity.Current topics in developmental biology · 2019Review
- Impact of immune activation on stored sperm viability in ant queens.Proceedings. Biological sciences · 2018Article
- Transcriptome sequencing reveals key potential long non-coding RNAs related to duration of fertility trait in the uterovaginal junction of egg-laying hens.Scientific reports · 2018Article
- The effects of a bacterial challenge on reproductive success of fruit flies evolved under low or high sexual selection.Ecology and evolution · 2018Article
- Juvenile Hormone Suppresses Resistance to Infection in Mated Female Drosophila melanogaster.Current biology : CB · 2017Article
- Global analysis of differential gene expression related to long-term sperm storage in oviduct of Chinese Soft-Shelled Turtle Pelodiscus sinensis.Scientific reports · 2016Article
- Do highly ornamented and less parasitized males have high quality sperm? - an experimental test for parasite-induced reproductive trade-offs in European minnow (Phoxinus phoxinus).Ecology and evolution · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All animals are under the constant threat of pathogenic infection. However, little is known regarding the influence of acute infection on sperm viability, particularly in female insects. This information is crucial for our understanding of mating and immune system coevolution, considering that females store sperm and serve as the site of sperm competition. Using the fruitfly, Drosophila melanogaster, we examined the influence of infection on sperm viability and storage. Twenty-four hours after haemocoel inoculation with a pathogen mimic (peptidoglycan, PGN) both sexes exhibited reduced sperm viability, indicating that systemic immune activation played a significant role in gamete survival. Surprisingly, sperm death did not appear to result from a reproductive-immune system trade-off, considering that sperm survived 24 h in vitro once removed from their somatic resources. Instead, our results are most consistent with death owing to immune effector collateral damage. We also examined the potential for sexually transmitted pathogens to influence sperm storage. Females mated with 'infected' males (created by dipping genitalia into a PGN solution) exhibited a higher proportion of empty sperm stores 48 h after mating compared to their controls. Remarkably, these data indicate that females may increase their fitness by removing 'infected' ejaculates from storage over time.
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