ArticleProteomics2012
Synaptic proteome changes in mouse brain regions upon auditory discrimination learning.
Article in Proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Synaptic proteomics identifies cathepsin B as a regulator of synapse remodelling during learning.bioRxiv : the preprint server for biology · 2026Article
- Complex Sound Discrimination in Zebrafish: Auditory Learning Within a Novel "Go/Go" Decision-Making Paradigm.Animals : an open access journal from MDPI · 2025Article
- Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.Journal of proteome research · 2025Article
- Striatal Transcriptome Reveals Differences Between Cognitively Impaired and Unimpaired Aged Male Rats.Frontiers in aging neuroscience · 2020Article
- Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance.Brain structure & function · 2018Article
- High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning.Journal of visualized experiments : JoVE · 2016Article
- Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain.Journal of neurochemistry · 2016Article
- Proteomics of the Synapse--A Quantitative Approach to Neuronal Plasticity.Molecular & cellular proteomics : MCP · 2016Review
- Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory.Frontiers in chemistry · 2016Review
- Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.Scientific reports · 2015Article
- Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.Frontiers in synaptic neuroscience · 2015Review
- Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.Proteome science · 2015Article
- Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera).Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- The roles of protein expression in synaptic plasticity and memory consolidation.Frontiers in molecular neuroscience · 2014Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in synaptic efficacy underlying learning and memory processes are assumed to be associated with alterations of the protein composition of synapses. Here, we performed a quantitative proteomic screen to monitor changes in the synaptic proteome of four brain areas (auditory cortex, frontal cortex, hippocampus striatum) during auditory learning. Mice were trained in a shuttle box GO/NO-GO paradigm to discriminate between rising and falling frequency modulated tones to avoid mild electric foot shock. Control-treated mice received corresponding numbers of either the tones or the foot shocks. Six hours and 24 h later, the composition of a fraction enriched in synaptic cytomatrix-associated proteins was compared to that obtained from naïve mice by quantitative mass spectrometry. In the synaptic protein fraction obtained from trained mice, the average percentage (±SEM) of downregulated proteins (59.9 ± 0.5%) exceeded that of upregulated proteins (23.5 ± 0.8%) in the brain regions studied. This effect was significantly smaller in foot shock (42.7 ± 0.6% down, 40.7 ± 1.0% up) and tone controls (43.9 ± 1.0% down, 39.7 ± 0.9% up). These data suggest that learning processes initially induce removal and/or degradation of proteins from presynaptic and postsynaptic cytoskeletal matrices before these structures can acquire a new, postlearning organisation. In silico analysis points to a general role of insulin-like signalling in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.