Trial reportEndoscopy2012
Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity.
Trial report in Endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Efficacy of innovative polyglycolic acid sheet device delivery station system: a randomized prospective study.Surgical endoscopy · 2018Trial
- The efficacy of topical bupivacaine and triamcinolone acetonide injection in the relief of pain after endoscopic submucosal dissection for gastric neoplasia: a randomized double-blind, placebo-controlled trial.Surgical endoscopy · 2015Trial
- Unavoidable human errors of tumor size measurement during specimen attachment after endoscopic resection: a clinical prospective study.PloS one · 2015Trial
- Laparoscopically assisted distal gastrectomy with Billroth I anastomosis for refractory gastric outlet obstruction after endoscopic submucosal dissection procedure: a case report.Journal of surgical case reports · 2025Article
- Treatment of Refractory Gastric Outlet Obstruction After Endoscopic Submucosal Dissection With Endoscopic Antralplasty and Stent Placement: A Case Report.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- A novel twin-grasper assisted mucosal inverted closure technique for closing large artificial gastric mucosal defects.Surgical endoscopy · 2024Article
- Supplementary uses for a novel injecting needle-knife that facilitate esophagogastric endoscopic submucosal dissection.Endoscopy · 2023Article
- Article
- Effects of steroid use for stenosis prevention after wide endoscopic submucosal dissection for gastric neoplasm.Surgical endoscopy · 2018Article
- Risk factors and management for gastric stenosis after endoscopic submucosal dissection for gastric epithelial neoplasm.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Article
- Updated evidence on endoscopic resection of early gastric cancer from Japan.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Review
- Risk factors and management for pyloric stenosis occurred after endoscopic submucosal dissection adjacent to pylorus.Medicine · 2016Article
- Stenosis rates after endoscopic submucosal dissection of large rectal tumors involving greater than three quarters of the luminal circumference.Surgical endoscopy · 2016Article
- Antral or Pyloric Deformity Is a Risk Factor for the Development of Postendoscopic Submucosal Dissection Pyloric Strictures.Gut and liver · 2016Article
- Stricture occurring after endoscopic submucosal dissection for esophageal and gastric tumors.Clinical endoscopy · 2014Review
- Novel method to prevent gastric antral strictures after endoscopic submucosal dissection: using triamcinolone.World journal of gastroenterology · 2014Article
- Endoscopic therapy for early gastric cancer: standard techniques and recent advances in ESD.World journal of gastroenterology · 2014Review
- Endoscopic submucosal dissection for treatment of gastric submucosal tumors originating from the muscularis propria layer.Digestive diseases and sciences · 2013Article
- Efficacy and safety of over-the-scope clip: including complications after endoscopic submucosal dissection.World journal of gastroenterology · 2013Article
- [Endoscopic submucosal dissection].Der Internist · 2013Review
Corrections and comments
- Commented on by
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimsEndoscopic submucosal dissection (ESD) of large gastric lesions results in an extensive artificial ulcer that can lead to marked gastric deformity. The aim of the current study was to evaluate therapeutic efficacy in the prevention of gastric deformity of local triamcinolone acetonide (TCA) injection into the extensive artificial ulcer following ESD. PATIENTS AND
methodsA total of 45 patients who were diagnosed with early gastric cancer were enrolled. Patients were randomly assigned by the sealed-envelope randomization method to either local TCA injections (n = 21) or sham-control (n = 20) groups. Two clips were placed at the two maximum outer edges of the artificial ulcer after the lesion had been resected (Day 0). Local TCA injections were performed on postoperative Day 5 and Day 12. The distance between the two clips was measured by endoscopic measuring forceps on Days 5, 12, 30, and 60. Granulation formation and gastric deformity were evaluated by visual analog scale (VAS) on Days 30 and 60.
resultsLocal TCA injection did not alter clip-to-clip distance on postoperative Day 60, and formation of flat granulation tissue over the ulcer was followed by regenerative mucosa without any gastric deformity. The sham-control group showed significant shortening of clip-to-clip distance compared with the local steroid-injected group and protruded forms of granulation tissue with mucosal convergence. Histological evaluation revealed prominent growth of neovessels, swelling, and marked increases in endothelial cells in the local steroid-injected group compared with the sham-control group.
conclusionsLocal steroid injection into the floor of a post-ESD artificial ulcer promotes the formation of granulation tissue at an early stage of the healing process leading to regeneration of gastric mucosa without mucosal convergence or gastric deformity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.