ArticleInsights into imaging2012
Quantification of iron concentration in the liver by MRI.
Article in Insights into imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Iron nanoparticles - biodistribution in the chicken embryo model.Biochemistry and biophysics reports · 2026Article
- Impact of environmental contaminants in fish on cell death and oxidative stress usingFood & nutrition research · 2025Article
- Quantification of liver iron overload among pediatric patients with magnetic resonance imaging: current state of the art.Polish journal of radiology · 2025Review
- Assessment of iron nanoparticle distribution in mouse models using ultrashort-echo-time MRI.NMR in biomedicine · 2022Article
- Determination of Non-Invasive Biomarkers for the Assessment of Fibrosis, Steatosis and Hepatic Iron Overload by MR Image Analysis. A Pilot Study.Diagnostics (Basel, Switzerland) · 2021Article
- Correlation of Serum Ferritin and Liver Iron Concentration with Transient Liver Elastography in Adult Thalassemia Intermedia Patients with Blood Transfusion.Journal of blood medicine · 2021Article
- Evaluation of liver iron overload with R2* relaxometry with versus without fat suppression: both are clinically accurate but there are differences.European radiology · 2020Article
- Liver involvement in patients with Gaucher disease types I and III.Molecular genetics and metabolism reports · 2020Article
- A positive influence of basal ganglia iron concentration on implicit sequence learning.Brain structure & function · 2020Article
- Serum ferritin levels and irregular use of iron chelators predict liver iron load in patients with major beta thalassemia: a cross-sectional study.Croatian medical journal · 2019Article
- Imaging features of thalassaemia.The British journal of radiology · 2019Review
- Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis.World journal of gastroenterology · 2019Article
- Demystifying liver iron concentration measurements with MRI.European radiology · 2018Article
- Ultra-short echo time images quantify high liver iron.Magnetic resonance in medicine · 2018Article
- The Author Replies.Kidney international reports · 2018Article
- The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis.International journal of hematology · 2018Review
- Iron Overload in Dialysis Patients: Rust or Bust?Kidney international reports · 2017Article
- Comparison between different software programs and post-processing techniques for the MRI quantification of liver iron concentration in thalassemia patients.La Radiologia medica · 2016Article
- Magnetic Resonance Elastography and Other Magnetic Resonance Imaging Techniques in Chronic Liver Disease: Current Status and Future Directions.Gut and liver · 2016Review
- Evaluation of Iron Deposition in the Adrenal Glands of β Thalassemia Major Patients Using 3-Tesla MRI.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMeasurement of liver iron concentration is a key parameter for the management of patients with primary and secondary haemochromatosis. Magnetic resonance imaging (MRI) has already demonstrated high accuracy to quantify liver iron content. To be able to improve the current management of patients that are found to have iron overload, we need a reproducible, standardised method that is, or can easily be made, widely available.
methodsThis article discusses the different MRI techniques and models to quantify liver iron concentration that are currently available and envisaged for the near future from a realistic perspective.
resultsT2 relaxometry methods are more accurate than signal intensity ratio (SIR) methods and they are reproducible but are not yet standardised or widely available. SIR methods, on the other hand, are very specific for all levels of iron overload and, what is more, they are also reproducible, standardised and already widely available.
conclusionsFor these reasons, today, both methods remain necessary while progress is made towards universal standardisation of the relaxometry technique.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.