ArticleInsights into imaging2012
Apparent diffusion coefficient measurements in the differentiation between benign and malignant lesions: a systematic review.
Article in Insights into imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic performance of apparent diffusion coefficient (ADC) for differentiating endometrial carcinoma from benign lesions: a systematic review and meta-analysis.Abdominal radiology (New York) · 2021Pooled it
- Diffusion-weighted MRI in differentiating malignant from benign thyroid nodules: a meta-analysis.BMJ open · 2016Pooled it
- Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard.European radiology · 2014Trial
- MRI findings for differentiating benign and malignant soft tissue tumors: a narrative review- Part 1: diagnostic performance.Skeletal radiology · 2026Review
- Influence of co-registration on lesion characterization in diffusion-weighted breast MRI.Magma (New York, N.Y.) · 2026Article
- The Heart-Brain Axis in the Context of Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- MICAFlow: Fast and robust MRI preprocessing bridging research neuroimaging and clinical practice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Choriocarcinoma at an Abdominal Wall Cesarean Scar: Recurrence After Multi-Line Chemotherapy and Exploration of Salvage Therapy.International journal of women's health · 2026Article
- Explainable incremental-value analysis of apparent diffusion coefficient and arterial spin labeling radiomics for ATRX status prediction in glioblastoma.Frontiers in oncology · 2026Article
- Diffusion-Weighted MRI as a Non-Invasive Diagnostic Tool for Ascites Characterization: A Comparative Analysis of Mean and Minimum ADC Values Against the Serum-Ascites Albumin Gradient.Diagnostics (Basel, Switzerland) · 2025Article
- Feasibility of high-resolution DWI of the healthy dental pulp in human using a hybrid TGSE BLADE sequence.Scientific reports · 2025Article
- Quantitative diffusion weighted imaging in patients with hepatocellular carcinoma: effects of simultaneous multi-slice acceleration and gadoxetic acid administration.Abdominal radiology (New York) · 2024Article
- Diffusion weighted imaging for improving the diagnostic performance of screening breast MRI: impact of apparent diffusion coefficient quantitation methods and cutoffs.Frontiers in oncology · 2024Article
- Imaging of thymic epithelial tumors-a clinical practice review.Mediastinum (Hong Kong, China) · 2024Review
- Computed diffusion-weighted imaging with a low-apparent diffusion coefficient-pixel cut-off technique for breast cancer detection.The British journal of radiology · 2023Article
- [Radiologic Evaluation of Uterine Lesions Using a Pattern Recognition Approach].Journal of the Korean Society of Radiology · 2023Review
- Whole-body [EJNMMI research · 2021Article
- Differentiating Between Low- and High-grade Glioma Tumors Measuring Apparent Diffusion Coefficient Values in Various Regions of the Brain.Oman medical journal · 2021Article
- Differentiating malignant from benign salivary gland lesions: a multiparametric non-contrast MR imaging approach.Scientific reports · 2021Article
- Applying Amide Proton Transfer-Weighted Imaging (APTWI) to Distinguish Papillary Thyroid Carcinomas and Predominantly Solid Adenomatous Nodules: Comparison With Diffusion-Weighted Imaging.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo systematically review the value of apparent diffusion coefficient (ADC) measurement in the differentiation between benign and malignant lesions.
methodsA systematic search of the Medline/Pubmed and Embase databases revealed 109 relevant studies. Quality of these articles was assessed using the Quality Assessment of the Studies of Diagnostic Accuracy Included in Systematic Reviews (QUADAS) criteria. Reported ADC values of benign and malignant lesions were compared per organ.
resultsThe mean quality score of the reviewed articles was 50%. Comparison of ADC values showed marked variation among studies and between benign and malignant lesions in various organs. In several organs, such as breast, liver, and uterus, ADC values discriminated well between benign and malignant lesions. In other organs, such as the salivary glands, thyroid, and pancreas, ADCs were not significantly different between benign and malignant lesions.
conclusionThe potential utility of ADC measurement for the characterisation of tumours differs per organ. Future well-designed studies are required before ADC measurements can be recommended for the differentiation of benign and malignant lesions. These future studies should use standardised acquisition protocols and provide complete reporting of study methods, to facilitate comparison of results and clinical implementation of ADC measurement for tumour characterisation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.