ReviewCancer immunology, immunotherapy : CII2012
The expression, function, and clinical relevance of B7 family members in cancer.
Review in Cancer immunology, immunotherapy : CII, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Prognostic role of B7-H4 in patients with non-small cell lung cancer: A meta-analysis.Oncotarget · 2017Pooled it
- Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.BioMed research international · 2015Trial
- The absence of B7-H4 inhibits PD-L1 expression by driving a methylation of PD-L1 promoter in breast cancer cells.Breast cancer research : BCR · 2026Article
- 3D Spheroids to Study the Impact of Immune Checkpoint Proteins in Solid Tumors.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Lypd6b depletion promotes CD8Nature communications · 2025Article
- Article
- Immunological mechanisms and antibody-drug conjugates targeting B7-H3 and B7-H4 in ovarian cancer.Frontiers in immunology · 2025Review
- Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review).International journal of oncology · 2024Review
- Immunoregulatory protein B7-H3 upregulated in bacterial and viral infection and its diagnostic potential in clinical settings.Frontiers in immunology · 2024Review
- PD-1/PD-L1 blockade inhibits epithelial-mesenchymal transition and improves chemotherapeutic response in breast cancer.Medical oncology (Northwood, London, England) · 2023Article
- Combining chemotherapy with CAR-T cell therapy in treating solid tumors.Frontiers in immunology · 2023Review
- SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling.The Journal of clinical investigation · 2022Article
- YH29407 with anti-PD-1 ameliorates anti-tumor effectsFrontiers in chemistry · 2022Article
- Prognostic factor analysis for patient outcome of PD-L1 expression in thoracic oesophageal squamous cell carcinoma.Interactive cardiovascular and thoracic surgery · 2021Article
- Expression and prognosis of the B7 family in acute myeloid leukemia.Annals of translational medicine · 2021Article
- B7-H3 is spliced by SRSF3 in colorectal cancer.Cancer immunology, immunotherapy : CII · 2021Article
- Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets.International journal of biological sciences · 2020Article
- The prognostic value of B7-H6 in esophageal squamous cell carcinoma.Scientific reports · 2019Article
- Article
- Clinical significance of novel costimulatory molecule B7-H6 in human breast cancer.Oncology letters · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modulation and suppression of anti-tumor immune responses is a characteristic feature of tumor cells to escape immune surveillance. Members of the B7 family are involved in this process, since the level of activation of the anti-tumor immune response depends on the balance between co-stimulatory and co-inhibitory signals. Some molecules are often overexpressed in tumors, which has been associated with the pathogenesis and progression of malignancies as well as their immunological and non-immunological functions. The B7 homologs play a key role in the maintenance of self-tolerance and the regulation of both innate and adaptive immunity in tumor-bearing hosts. Furthermore, the blockade of negative signals mediated by the interaction of co-inhibitory ligands and counter-receptors of the B7 family is currently being studied as a potential immunotherapeutic strategy for the treatment of cancer in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.