ArticleMolecules (Basel, Switzerland)2012
Aqueous extracts of the edible Gracilaria tenuistipitata are protective against H₂O₂-induced DNA damage, growth inhibition, and cell cycle arrest.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Biotechnological Applications of Biogenic Nanomaterials from Red Seaweed: A Systematic Review (2014-2024).International journal of molecular sciences · 2025Pooled it
- A novel bacterial symbiont in the seaweedFrontiers in microbiology · 2026Article
- Overcoming Extraction Hurdles and Assessing Biological Activity in a Major Invasive Seaweed Species in Europe,Marine drugs · 2025Article
- Effect of Spirulina and Fish Processing By-Products Extracts on Citrinin-Induced Cytotoxicity in SH-SY5Y Cells.Foods (Basel, Switzerland) · 2024Article
- A 70% EthanolMolecules (Basel, Switzerland) · 2024Article
- Biostimulant red seaweed (PeerJ · 2023Article
- Improvement of Phenolic Compound Extraction by Using Ion Exchange Chromatography and Evaluation of Biological Activities of Polyphenol-enriched Fraction ofIranian journal of pharmaceutical research : IJPR · 2022Article
- Novel Technologies for Seaweed Polysaccharides Extraction and Their Use in Food with Therapeutically Applications-A Review.Foods (Basel, Switzerland) · 2022Review
- BioengineeredToxics · 2021Article
- Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review.Molecules (Basel, Switzerland) · 2020Review
- Valorization of Waste Water ofTheScientificWorldJournal · 2020Article
- Targeting acquired oncogenic burden in resilient pancreatic cancer: a novel benefit from marine polyphenols.Molecular and cellular biochemistry · 2019Article
- Adverse effect of nano-TiORSC advances · 2018Article
- Human Lymphocyte-Protective Effects of an Ethanol Extract fromAntioxidants (Basel, Switzerland) · 2018Article
- Complete sequence of mitochondrial DNA ofMitochondrial DNA. Part B, Resources · 2018Article
- The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production.Marine drugs · 2017Article
- Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.Oncotarget · 2017Article
- Article
- Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.Frontiers in physiology · 2017Article
- APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells.Marine drugs · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potential antioxidant properties of an aqueous extract of the edible red seaweed Gracilaria tenuistipitata (AEGT) against oxidative DNA damage were evaluated. The AEGT revealed several antioxidant molecules, including phenolics, flavonoids and ascorbic acid. In a cell-free assay, the extract exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity that significantly reduced H₂O₂-induced plasmid DNA breaks in a dose-response manner (P < 0.001). The AEGT also suppressed H₂O₂-induced oxidative DNA damage in H1299 cells by reducing the percentage of damaged DNA in a dose-response manner (P < 0.001) as measured by a modified alkaline comet-nuclear extract (comet-NE) assay. The MTT assay results showed that AEGT confers significant protection against H₂O₂-induced cytotoxicity and that AEGT itself is not cytotoxic (P < 0.001). Moreover, H₂O₂-induced cell cycle G2/M arrest was significantly released when cells were co-treated with different concentrations of AEGT (P < 0.001). Taken together, these findings suggest that edible red algae Gracilaria water extract can prevent H₂O₂-induced oxidative DNA damage and its related cellular responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.