Evidence map›Paper›PMID 22695164›Full record

ArticleClinical and vaccine immunology : CVI2012

Role of signal-to-cutoff ratios in hepatitis C virus antibody detection.

Marco Moretti, Barbara Pieretti, Annamaria Masucci, Davide Sisti, Marco Rocchi, Ernesto Delprete

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. KASL clinical practice guidelines: management of hepatitis C.Clinical and molecular hepatology · 2016
    Guideline
  2. KASL clinical practice guidelines: management of hepatitis C.Clinical and molecular hepatology · 2014
    Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hepatitis C Virus Screening: A Review of the OraQuick Hepatitis C Virus Rapid Antibody Test.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2015
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco MorettiLaboratorio Patologia Clinica, Ospedale S. Croce, A.O.R.M.N., Fano, Italy. marcomoretti18@libero.it
Barbara Pieretti
Annamaria Masucci
Davide Sisti
Marco Rocchi
Ernesto Delprete

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reviewed results from 12,800 samples tested for hepatitis C virus (HCV) antibody detection in our laboratory by screening (Ortho chemiluminescence immunoassay [CIA]) and supplemental tests (Chiron recombinant immunoblot assay [RIBA]). We found that a signal-to-cutoff (S/Co) ratio of 10.3 was, in our setting, the most efficient cutoff point to improve the diagnostic algorithm of HCV infection.

Indexed as

Clinical Laboratory TechniquesHepacivirusHepatitis CHepatitis C AntibodiesHumansImmunoassayHepatitis C Antibodies

Identifiers

PMID22695164
PMCPMC3416074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.