ArticleClinical and vaccine immunology : CVI2012
Field application of serodiagnostics to identify elephants with tuberculosis prior to case confirmation by culture.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Diagnosis of tuberculosis in wildlife: a systematic review.Veterinary research · 2021Pooled it
- Human risk factors associated with the presence of antibodies againstOne health (Amsterdam, Netherlands) · 2026Article
- Seroprevalence of tuberculosis and hematological variations in captive and orphaned wild elephants (Elephas maximus maximus) in Sri Lanka.Veterinary research communications · 2026Article
- Article
- Differentially Represented Proteins in Response to Infection withPathogens (Basel, Switzerland) · 2022Article
- Monitoring IgG against Mycobacterium tuberculosis proteins in an Asian elephant cured of tuberculosis that developed from long-term latency.Scientific reports · 2022Article
- Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal.The Journal of veterinary medical science · 2021Article
- Prevalence and Demographic Risk Factors ofFrontiers in veterinary science · 2021Article
- Detection of Mycobacterium tuberculosis complex infection in Asian elephants (Elephas maximus) using an interferon gamma release assay in a captive elephant herd.Scientific reports · 2020Article
- Mycobacterium caprae Infection in Captive Borneo Elephant, Japan.Emerging infectious diseases · 2018Article
- Comparison of cortisol and thyroid hormones between tuberculosis-suspect and healthy elephants of Nepal.The Journal of veterinary medical science · 2016Article
- Tuberculosis in Laos, who is at risk: the mahouts or their elephants?Epidemiology and infection · 2015Article
- Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Antibodies against Mycobacterial proteins as biomarkers for HIV-associated smear-negative tuberculosis.Clinical and vaccine immunology : CVI · 2014Article
- Serodiagnosis of tuberculosis in Asian elephants (Elephas maximus) in Southern India: a latent class analysis.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three serologic methods for antibody detection in elephant tuberculosis (TB), the multiantigen print immunoassay (MAPIA), ElephantTB STAT-PAK kit, and DPP VetTB test, were evaluated using serial serum samples from 14 captive elephants infected with Mycobacterium tuberculosis in 5 countries. In all cases, serological testing was performed prior to the diagnosis of TB by mycobacterial culture of trunk wash or tissue samples collected at necropsy. All elephants produced antibody responses to M. tuberculosis antigens, with 13/14 recognizing ESAT-6 and/or CFP10 proteins. The findings supported the high serodiagnostic test accuracy in detecting infections months to years before M. tuberculosis could be isolated from elephants. The MAPIA and/or DPP VetTB assay demonstrated the potential for monitoring antimycobacterial therapy and predicting TB relapse in treated elephants when continuously used in the posttreatment period. History of exposure to TB and past treatment information should be taken into consideration for proper interpretation of the antibody test results. Data suggest that the more frequent trunk wash culture testing of seropositive elephants may enhance the efficiency of the TB diagnostic algorithm, leading to earlier treatment with improved outcomes.
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