Evidence map›Paper›PMID 22695054›Full record

ArticleBMC pulmonary medicine2012

The prevalence of clinically-relevant comorbid conditions in patients with physician-diagnosed COPD: a cross-sectional study using data from NHANES 1999-2008.

Kerry Schnell, Carlos O Weiss, Todd Lee, Jerry A Krishnan, Bruce Leff, Jennifer L Wolff, Cynthia Boyd

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01833026 (Comparative Effectiveness of COPD Assessment and Management Bundle Versus Usual Care in Patients Suspected of Having COPD), which is not on this map. Cited by 126 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 13 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01833026 nacompletednot on this mapstarted 2013, after this paper: background citation

Comparative Effectiveness of COPD Assessment and Management Bundle Versus Usual Care in Patients Suspected of Having COPD

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2013 to 2016Enrolled56ConditionsChronic Obstructive Pulmonary DiseaseArmsSpirometry test, Levalbuterol
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 13 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. Pooled it
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  5. Guideline
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  7. Chronic Obstructive Pulmonary Disease and the Risk of Stroke.Annals of the American Thoracic Society · 2017
    Pooled it
  8. Pooled it
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  10. Pooled it
  11. Self management for patients with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2014
    Pooled it
  12. Pooled it
  13. Prevalence of osteoarthritis in individuals with COPD: a systematic review.International journal of chronic obstructive pulmonary disease
    Pooled it
  14. Trial
  15. Trial
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  17. Article
  18. Article
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  20. Review

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kerry SchnellJohns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA. kschnel1@jhmi.edu
Carlos O Weiss
Todd Lee
Jerry A Krishnan
Bruce Leff
Jennifer L Wolff
Cynthia Boyd
Johns Hopkins University · USUniversity of Baltimore · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Institute for Clinical and Translational Research (TL1)TL1RR025007 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$2.6M
Optimizing Family Involvement in Late-Life Depression CareK01MH082885 · NIMH · JOHNS HOPKINS UNIVERSITY · PI WOLFF, JENNIFER L. · 2009 to 2013
$755k
Treatment Burden in Older Adults with Diabetes and MultimorbidityK23AG032910 · NIA · JOHNS HOPKINS UNIVERSITY · PI BOYD, CYNTHIA MELINDA · 2009 to 2013
$533k
NCRR NIH HHS 1TL1RR-025007NIA NIH HHS K23 AG032910NIMH NIH HHS K01 MH082885-2
6 · The paper itself

Abstract

backgroundTreatment of chronic diseases such as chronic obstructive pulmonary disease (COPD) is complicated by the presence of comorbidities. The objective of this analysis was to estimate the prevalence of comorbidity in COPD using nationally-representative data.

methodsThis study draws from a multi-year analytic sample of 14,828 subjects aged 45+, including 995 with COPD, from the National Health and Nutrition Examination Survey (NHANES), 1999-2008. COPD was defined by self-reported physician diagnosis of chronic bronchitis or emphysema; patients who reported a diagnosis of asthma were excluded. Using population weights, we estimated the age-and-gender-stratified prevalence of 22 comorbid conditions that may influence COPD and its treatment.

resultsSubjects 45+ with physician-diagnosed COPD were more likely than subjects without physician-diagnosed COPD to have coexisting arthritis (54.6% vs. 36.9%), depression (20.6% vs. 12.5%), osteoporosis (16.9% vs. 8.5%), cancer (16.5% vs. 9.9%), coronary heart disease (12.7% vs. 6.1%), congestive heart failure (12.1% vs. 3.9%), and stroke (8.9% vs. 4.6%). Subjects with COPD were also more likely to report mobility difficulty (55.6% vs. 32.5%), use of >4 prescription medications (51.8% vs. 32.1), dizziness/balance problems (41.1% vs. 23.8%), urinary incontinence (34.9% vs. 27.3%), memory problems (18.5% vs. 8.8%), low glomerular filtration rate (16.2% vs. 10.5%), and visual impairment (14.0% vs. 9.6%). All reported comparisons have p < 0.05.

conclusionsOur study indicates that COPD management may need to take into account a complex spectrum of comorbidities. This work identifies which conditions are most common in a nationally-representative set of COPD patients (physician-diagnosed), a necessary step for setting research priorities and developing clinical practice guidelines that address COPD within the context of comorbidity.

Indexed as

AgedAged, 80 and overAge DistributionComorbidityFemaleHumansMaleMiddle AgedNutrition SurveysPrevalencePulmonary Disease, Chronic ObstructiveSex DistributionSmokingUnited States

Identifiers

PMID22695054
PMCPMC3461433
OpenAlexW2010471452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.