ArticleAddictive behaviors2012
Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.
Article in Addictive behaviors, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence of CNIH3 involvement in opioid dependence.Molecular psychiatry · 2016Pooled it
- Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes.Addiction biology · 2020Trial
- Reduced volume of the nucleus accumbens in heroin addiction.European archives of psychiatry and clinical neuroscience · 2015Trial
- Cluster analysis to identify patient profiles and substance use patterns among pregnant persons with opioid use disorder.Addictive behaviors reports · 2023Article
- Novel digital approaches to the assessment of problematic opioid use.BioData mining · 2022Review
- Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example.Drug and alcohol dependence · 2021Article
- Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients.The international journal of neuropsychopharmacology · 2021Article
- Are Machine Learning Methods the Future for Smoking Cessation Apps?Sensors (Basel, Switzerland) · 2021Article
- Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice.Frontiers in behavioral neuroscience · 2021Article
- Beyond abstinence and relapse: cluster analysis of drug-use patterns during treatment as an outcome measure for clinical trials.Psychopharmacology · 2020Article
- Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence.BMC medical genetics · 2020Article
- Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry.Journal of studies on alcohol and drugs · 2019Article
- Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2017Article
- Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders.Biological psychiatry · 2016Review
- Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.Addictive behaviors · 2016Article
- Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.Alcoholism, clinical and experimental research · 2015Review
- Article
- Refining multivariate disease phenotypes for high chip heritability.BMC medical genomics · 2015Article
- The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men.Alcoholism, clinical and experimental research · 2014Article
- Multi-view singular value decomposition for disease subtyping and genetic associations.BMC genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Although there is evidence that opioid dependence (OD) is heritable, efforts to identify genes contributing to risk for the disorder have been hampered by its complex etiology and variable clinical manifestations. Decomposition of a complex set of opioid users into homogeneous subgroups could enhance genetic analysis. We applied a series of data mining techniques, including multiple correspondence analysis, variable selection and cluster analysis, to 69 opioid-related measures from 5390 subjects aggregated from family-based and case-control genetic studies to identify homogeneous subtypes and estimate their heritability. Novel aspects of this work include our use of (1) heritability estimates of specific clinical features of OD to enhance the heritability of the subtypes and (2) a k-medoids clustering method in combination with hierarchical clustering to yield replicable clusters that are less sensitive to noise than previous methods. We identified five homogeneous groups, including two large groups comprised of 762 and 1353 heavy opioid users, with estimated heritability of 0.69 and 0.76, respectively. These methods represent a promising approach to the identification of highly heritable subtypes in complex, heterogeneous disorders.
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