ArticleThe Journal of allergy and clinical immunology2012
Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06625216 (Observatory of Patients With Severe Asthma and Potential Eligible Patients for Treatment With Biological Drugs), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observatory of Patients With Severe Asthma and Potential Eligible Patients for Treatment With Biological Drugs
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of Sex on Prediction of Asthma Attacks by Clinical Risk Factors and Type 2 Biomarkers.Chest · 2026Pooled it
- Fish and fish oil intake in relation to risk of asthma: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Digital Action Plan (Web App) for Managing Asthma Exacerbations: Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma.BMC pulmonary medicine · 2019Trial
- Evaluation of a web-based asthma self-management system: a randomised controlled pilot trial.BMC pulmonary medicine · 2015Trial
- Rhinovirus-infected preschool children with problematic wheeze have lung eosinophilic inflammation.The Journal of allergy and clinical immunology · 2026Article
- Enhancing procedural quality and efficiency of methacholine bronchial challenge tests in patients with suspected cough-variant asthma: a quasi-experimental study utilizing nurse-patient communication and respiratory training.Frontiers in medicine · 2026Article
- Short-Term Prognosis in Acute Asthma Exacerbations: A Comparative Evaluation of Machine Learning Models Using Spirometry and Tracheal Respiratory Sound Analysis.International journal of general medicine · 2026Article
- Prognostic utility of pre-biologic treatment correlates of childhood severe asthma exacerbation risk: Real world evidence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Navigating childhood asthma care in Kenya: barriers identified by children and their caregivers.BMC pediatrics · 2025Article
- Evaluation of Asthma Course in Patients Hospitalized in Pediatric Intensive Care Unit Due to Severe Asthma Exacerbation.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery.Exploration (Beijing, China) · 2025Review
- Family Physicians' Awareness of the Burden of Oral Corticosteroids in Asthma Patients.Acta medica academica · 2024Observational
- Association of Obesity and Severe Asthma in Adults.Journal of clinical medicine · 2024Review
- Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Associations between Occupational Asthma and Obesity in the Central Region of Tunisia.Tanaffos · 2023Article
- Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS).Clinical and translational allergy · 2022Article
- Long-Term Natural History of Severe Asthma Exacerbations and Their Impact on the Disease Course.Annals of the American Thoracic Society · 2022Article
- The new era of add-on asthma treatments: where do we stand?Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Patients with severe or difficult-to-treat asthma are an understudied population but account for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study was a large, 3-year, multicenter, observational cohort study of 4756 patients (n=3489 adults ≥ 18 years of age, n=497 adolescents 13-17 years of age, and n=770 children 6-12 years of age) with severe or difficult-to-treat asthma. TENOR's primary objective was to characterize the natural history of disease in this cohort. Data assessed semiannually and annually included demographics, medical history, comorbidities, asthma control, asthma-related health care use, medication use, lung function, IgE levels, self-reported asthma triggers, and asthma-related quality of life. We highlight the key findings and clinical implications from more than 25 peer-reviewed TENOR publications. Regardless of age, patients with severe or difficult-to-treat asthma demonstrated high rates of health care use and substantial asthma burden despite receiving multiple long-term controller medications. Recent exacerbation history was the strongest predictor of future asthma exacerbations. Uncontrolled asthma, as defined by the 2007 National Heart, Lung, and Blood Institute guidelines' impairment domain, was highly prevalent and predictive of future asthma exacerbations; this assessment can be used to identify high-risk patients. IgE and allergen sensitization played a role in the majority of severe or difficult-to-treat asthmatic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.