ArticleBurns : journal of the International Society for Burn Injuries2013
Vagus nerve stimulation blocks vascular permeability following burn in both local and distal sites.
Article in Burns : journal of the International Society for Burn Injuries, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Long-term vagus nerve stimulation synergized with rapamycin elicits neuroimmune modulation to prolong skin allograft survival.iScience · 2026Article
- Review
- Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function.Brain, behavior, and immunity · 2015Article
- NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have shown that vagus nerve stimulation (VNS) can block the burn-induced systemic inflammatory response (SIRS). In this study we examined the potential for VNS to modulate vascular permeability (VP) in local sites (i.e. skin) and in secondary sites (i.e. lung) following burn. In a 30% total body surface area burn model, VP was measured using intravascular fluorescent dextran for quantification of the VP response in skin and lung. A peak in VP of the skin was observed 24h post-burn injury, that was blocked by VNS. Moreover, in the lung, VNS led to a reduction in burn-induced VP compared to sham-treated animals subjected to burn alone. The protective effects of VNS in this model were independent of the spleen, suggesting that the spleen was not a direct mediator of VNS. These studies identify a role for VNS in the regulation of VP in burns, with the translational potential of attenuating lung complications following burn.
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Registered trials
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