ArticlePloS one2012
Altered velocity processing in schizophrenia during pursuit eye tracking.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effects of ketamine on brain function during smooth pursuit eye movements.Human brain mapping · 2016Trial
- Relationship Between Visual Integration, Social Cognition, and Symptoms in Schizophrenia: An Eye-Tracking Study.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Article
- Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia.Current topics in behavioral neurosciences · 2025Review
- Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect.Scientific reports · 2023Article
- Neural mechanisms of background and velocity effects in smooth pursuit eye movements.Human brain mapping · 2023Article
- Eye movement characteristics in schizophrenia: A recent update with clinical implications.Neuropsychopharmacology reports · 2020Review
- Free visual exploration of natural movies in schizophrenia.European archives of psychiatry and clinical neuroscience · 2019Article
- Visualization and quantification of eye tracking data for the evaluation of oculomotor function.Heliyon · 2019Article
- Using Smooth Pursuit Calibration for Difficult-to-Calibrate Participants.Journal of eye movement research · 2017Article
- Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2017Article
- Impaired top-down modulation of saccadic latencies in patients with schizophrenia but not in first-degree relatives.Frontiers in behavioral neuroscience · 2015Article
- Neural mechanisms of smooth pursuit eye movements in schizotypy.Human brain mapping · 2015Article
- Vergence eye movements in patients with schizophrenia.Vision research · 2014Article
- Efference copy failure during smooth pursuit eye movements in schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Eye-head coordination abnormalities in schizophrenia.PloS one · 2013Article
- Small Saccades and Image Complexity during Free Viewing of Natural Images in Schizophrenia.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Smooth pursuit eye movements (SPEM) are needed to keep the retinal image of slowly moving objects within the fovea. Depending on the task, about 50%-80% of patients with schizophrenia have difficulties in maintaining SPEM. We designed a study that comprised different target velocities as well as testing for internal (extraretinal) guidance of SPEM in the absence of a visual target. We applied event-related fMRI by presenting four velocities (5, 10, 15, 20°/s) both with and without intervals of target blanking. 17 patients and 16 healthy participants were included. Eye movements were registered during scanning sessions. Statistical analysis included mixed ANOVAs and regression analyses of the target velocity on the Blood Oxygen Level Dependency (BOLD) signal. The main effect group and the interaction of velocity×group revealed reduced activation in V5 and putamen but increased activation of cerebellar regions in patients. Regression analysis showed that activation in supplementary eye field, putamen, and cerebellum was not correlated to target velocity in patients in contrast to controls. Furthermore, activation in V5 and in intraparietal sulcus (putative LIP) bilaterally was less strongly correlated to target velocity in patients than controls. Altered correlation of target velocity and neural activation in the cortical network supporting SPEM (V5, SEF, LIP, putamen) implies impaired transformation of the visual motion signal into an adequate motor command in patients. Cerebellar regions seem to be involved in compensatory mechanisms although cerebellar activity in patients was not related to target velocity.
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