SynthesisPloS one2012
Seasonality of rotavirus in South Asia: a meta-analysis approach assessing associations with temperature, precipitation, and vegetation index.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 9 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Epidemiological characteristics of rotavirus gastroenteritis in China: A systematic review of studies published from 2014 to 2023.Human vaccines & immunotherapeutics · 2026Pooled it
- Epidemiology, genetic diversity and symptom characterization ofFrontiers in microbiology · 2025Pooled it
- Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis.Frontiers in immunology · 2023Pooled it
- The effect and attributable risk of daily temperature on category C infectious diarrhea in Guangdong Province, China.Environmental science and pollution research international · 2022Pooled it
- Temperature and risk of infectious diarrhea: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Climatic Drivers of Diarrheagenic Escherichia coli Incidence: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2016Pooled it
- Untangling the Impacts of Climate Change on Waterborne Diseases: a Systematic Review of Relationships between Diarrheal Diseases and Temperature, Rainfall, Flooding, and Drought.Environmental science & technology · 2016Pooled it
- A systematic review and meta-analysis of ambient temperature and diarrhoeal diseases.International journal of epidemiology · 2016Pooled it
- Pooled it
- Seasonality of underweight among infants 1-11 months old in Niger: an exploratory analysis of data from a cluster-randomised trial.BMJ global health · 2025Trial
- Risk factors associated with recurrent diarrheal illnesses among children in Kabul, Afghanistan: a prospective cohort study.PloS one · 2015Trial
- Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination.PloS one · 2014Trial
- Effects of climatic factors on rotavirus infection in Bangladesh: a time series analysis and future projections.Global health action · 2026Article
- Waterborne diseases and climate change.Nature reviews. Microbiology · 2026Review
- Vulnerability to climate-driven pathogen-specific diarrheal diseases: secondary analysis from the Global Enteric Multicenter Study and Vaccine Impact on Diarrhea in Africa follow-up.Nature communications · 2026Article
- Seasonality and risk factors of relapse to acute malnutrition: a multi-country prospective cohort study in Mali, South Sudan, and Somalia, 2021-2022.Journal of public health policy · 2026Article
- Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and Meta-Analysis.Journal of tropical medicine · 2026Review
- Epidemiology and Antibiotic Resistance of Foodborne Diseases Among Children in Shanghai: A Four-Year Surveillance Study, 2021-2024.Infection and drug resistance · 2026Article
- Epidemiology of Rotavirus Gastroenteritis in Children Under Five in Maharashtra, India: A Multicenter Surveillance Study After Vaccine Introduction.Indian journal of pediatrics · 2025Article
- Comparison of Clinical Profiles and Trends of Rotavirus Gastroenteritis in the Prevaccine and Postvaccine Periods Among Children Aged Under 5 Years in the Western States of Gujarat and Maharashtra, India.Indian journal of pediatrics · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundRotavirus infection causes a significant proportion of diarrhea in infants and young children worldwide leading to dehydration, hospitalization, and in some cases death. Rotavirus infection represents a significant burden of disease in developing countries, such as those in South Asia.
methodsWe conducted a meta-analysis to examine how patterns of rotavirus infection relate to temperature and precipitation in South Asia. Monthly rotavirus data were abstracted from 39 published epidemiological studies and related to monthly aggregated ambient temperature and cumulative precipitation for each study location using linear mixed-effects models. We also considered associations with vegetation index, gathered from remote sensing data. Finally, we assessed whether the relationship varied in tropical climates and humid mid-latitude climates.
resultsOverall, as well as in tropical and humid mid-latitude climates, low temperature and precipitation levels are significant predictors of an increased rate of rotaviral diarrhea. A 1°C decrease in monthly ambient temperature and a decrease of 10 mm in precipitation are associated with 1.3% and 0.3% increase above the annual level in rotavirus infections, respectively. When assessing lagged relationships, temperature and precipitation in the previous month remained significant predictors and the association with temperature was stronger in the tropical climate. The same association was seen for vegetation index; a seasonal decline of 0.1 units results in a 3.8% increase in rate of rotavirus.
conclusionsIn South Asia the highest rate of rotavirus was seen in the colder, drier months. Meteorological characteristics can be used to better focus and target public health prevention programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.