ArticlePloS one2012
The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease.Bone research · 2026Review
- FGF signaling in cranial suture development and related diseases.Frontiers in cell and developmental biology · 2023Review
- BMP2 as a promising anticancer approach: functions and molecular mechanisms.Investigational new drugs · 2022Review
- Whole-genome SNP markers reveal conservation status, signatures of selection, and introgression in Chinese Laiwu pigs.Evolutionary applications · 2021Article
- Growth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells.Bone research · 2020Article
- Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation.International journal of molecular sciences · 2020Article
- Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.Nucleic acids research · 2020Article
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- BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells.Frontiers in cell and developmental biology · 2020Review
- WidespreadGenome research · 2019Article
- Microparticles for controlled growth differentiation factor 6 delivery to direct adipose stem cell-based nucleus pulposus regeneration.Journal of tissue engineering and regenerative medicine · 2019Article
- A coupled reaction-diffusion-strain model predicts cranial vault formation in development and disease.Biomechanics and modeling in mechanobiology · 2019Article
- PIN1 is a new therapeutic target of craniosynostosis.Human molecular genetics · 2018Article
- TGF-β Family Signaling in Mesenchymal Differentiation.Cold Spring Harbor perspectives in biology · 2018Review
- Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.The Journal of clinical investigation · 2018Article
- Genetic advances in craniosynostosis.American journal of medical genetics. Part A · 2017Review
- Signaling networks in joint development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Growth Differentiation Factor-6 (Gdf6) is a member of the Bone Morphogenetic Protein (BMP) family of secreted signaling molecules. Previous studies have shown that Gdf6 plays a role in formation of a diverse subset of skeletal joints. In mice, loss of Gdf6 results in fusion of the coronal suture, the intramembranous joint that separates the frontal and parietal bones. Although the role of GDFs in the development of cartilaginous limb joints has been studied, limb joints are developmentally quite distinct from cranial sutures and how Gdf6 controls suture formation has remained unclear. In this study we show that coronal suture fusion in the Gdf6-/- mouse is due to accelerated differentiation of suture mesenchyme, prior to the onset of calvarial ossification. Gdf6 is expressed in the mouse frontal bone primordia from embryonic day (E) 10.5 through 12.5. In the Gdf6-/- embryo, the coronal suture fuses prematurely and concurrently with the initiation of osteogenesis in the cranial bones. Alkaline phosphatase (ALP) activity and Runx2 expression assays both showed that the suture width is reduced in Gdf6+/- embryos and is completely absent in Gdf6-/- embryos by E12.5. ALP activity is also increased in the suture mesenchyme of Gdf6+/- embryos compared to wild-type. This suggests Gdf6 delays differentiation of the mesenchyme occupying the suture, prior to the onset of ossification. Therefore, although BMPs are known to promote bone formation, Gdf6 plays an inhibitory role to prevent the osteogenic differentiation of the coronal suture mesenchyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.