Evidence map›Paper›PMID 22693508›Full record

ArticleInternational journal of dentistry2012

Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria.

Masahiro Yoneda, Nao Suzuki, Yosuke Masuo, Akie Fujimoto, Kosaku Iha, Kazuhiko Yamada, Tomoyuki Iwamoto, Takao Hirofuji

Registry-linked trialAbstract read
In one paragraph

Article in International journal of dentistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06875544 (Clinical Performance of High Viscosity Bioactive Injectable Composite in Deep Marginal Elevation Randomized Controlled Trail), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06875544 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Performance of High Viscosity Bioactive Injectable Composite in Deep Marginal Elevation Randomized Controlled Trail

TypeinterventionalSponsorFuture University in EgyptRan2025 to 2026Enrolled50ConditionsDME, Dental, Deep Margin ElevationArmsBeautifil F00, G-aenial Universal Injectable Flowable Composite
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Biological Effects on S-PRG: An Integrative Review.Journal of functional biomaterials · 2026
    Review
  2. Article
  3. Article
  4. Association BetweenInfection and drug resistance · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Therapeutic polymers for dental adhesives: loading resins with bio-active components.Dental materials : official publication of the Academy of Dental Materials · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masahiro YonedaCenter for Oral Diseases, Fukuoka Dental College, 3-2-1 Hakataekimae, Hakata-ku 812-0011, Japan.
Nao Suzuki
Yosuke Masuo
Akie Fujimoto
Kosaku Iha
Kazuhiko Yamada
Tomoyuki Iwamoto
Takao Hirofuji

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed. We examined the effect of an S-PRG eluate on various biologic activities of Streptococcus mutans and Porphyromonas gingivalis. Adherence ability of S. mutans was evaluated by microtiter plate assay; protease and gelatinase activities of P. gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively. Coaggregation of P. gingivalis with Fusobacterium nucleatum was also examined. S-PRG eluate was found to suppress streptococcal adherence. S-PRG eluate inhibited the protease and gelatinase activities of P. gingivalis and the coaggregation between P. gingivalis and F. nucleatum. These results indicate that S-PRG eluate suppresses streptococcal adherence and inhibits the protease and coaggregation activities of P. gingivalis. These findings may prompt research into novel strategies for preventing caries and periodontitis.

Identifiers

PMID22693508
PMCPMC3368200

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.