ArticleAmerican journal of physiology. Endocrinology and metabolism2012
Developmental changes in embryonic hypothalamic neurons during prenatal fat exposure.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring.Journal of neurochemistry · 2025Review
- Maternal-infant nutrition and development programming of offspring appetite and obesity.Nutrition reviews · 2020Review
- Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice.Molecular and cellular biology · 2020Article
- Behavioral Feeding Circuit: Dietary Fat-Induced Effects of Inflammatory Mediators in the Hypothalamus.Frontiers in endocrinology · 2020Review
- IDOL regulates systemic energy balance through control of neuronal VLDLR expression.Nature metabolism · 2019Article
- Early life high-fat diet exposure maintains glucose tolerance and insulin sensitivity with a fatty liver and small brain size in the adult offspring.Nutrition research (New York, N.Y.) · 2019Article
- Increased Hypothalamic Projections to the Lateral Hypothalamus and Responses to Leptin in Rat Neonates From High Fat Fed Mothers.Frontiers in neuroscience · 2019Article
- Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy.The Journal of clinical investigation · 2018Article
- Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation.Oncotarget · 2017Article
- Orexin/Hypocretin System: Role in Food and Drug Overconsumption.International review of neurobiology · 2017Review
- Involvement of the CXCL12 System in the Stimulatory Effects of Prenatal Exposure to High-Fat Diet on Hypothalamic Orexigenic Peptides and Behavior in Offspring.Frontiers in behavioral neuroscience · 2017Article
- Prenatal fat-rich diet exposure alters responses of embryonic neurons to the chemokine, CCL2, in the hypothalamus.Neuroscience · 2016Article
- Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons.Peptides · 2016Article
- Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms.Frontiers in nutrition · 2016Review
- Relationship of the Chemokine, CXCL12, to Effects of Dietary Fat on Feeding-Related Behaviors and Hypothalamic Neuropeptide Systems.Frontiers in behavioral neuroscience · 2016Article
- Regulation of the orexigenic neuropeptide, enkephalin, by PPARδ and fatty acids in neurons of the hypothalamus and forebrain.Journal of neurochemistry · 2015Article
- Stimulatory role of the chemokine CCL2 in the migration and peptide expression of embryonic hypothalamic neurons.Journal of neurochemistry · 2014Article
- Maternal obesity induced by a high fat diet causes altered cellular development in fetal brains suggestive of a predisposition of offspring to neurological disorders in later life.Metabolic brain disease · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Maternal consumption of a fat-rich diet during pregnancy, which causes later overeating and weight gain in offspring, has been shown to stimulate neurogenesis and increase hypothalamic expression of orexigenic neuropeptides in these postnatal offspring. The studies here, using an in vitro model that mimics in vivo characteristics after prenatal high-fat diet (HFD) exposure, investigate whether these same peptide changes occur in embryos and if they are specific to neurons. Isolated hypothalamic neurons were compared with whole hypothalamus from embryonic day 19 (E19) embryos that were prenatally exposed to HFD and were both found to show similar increases in mRNA expression of enkephalin (ENK) and neuropeptide Y (NPY) compared with that of chow-exposed embryos, with no change in melanin-concentrating hormone, orexin, or galanin. Further examination using immunofluorescence cytochemistry revealed an increase in the number of cells expressing ENK and NPY. By plotting the fluorescence intensity of each cell as a probability density function, three different populations of neurons with low, medium, or high levels of ENK or NPY were found in both HFD and chow groups. The prenatal HFD shifted the density of neurons from the population containing low peptide levels to the population containing high peptide levels. This study indicates that neuronal culture is a useful in vitro system for studying diet effects on neuronal development and shows that prenatal HFD exposure alters the population of hypothalamic neurons containing ENK and NPY in the embryo. These changes may contribute to the increase in HFD intake and body weight observed in offspring.
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