ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed.
- Neural Sensitivity to Conversational Inter-Speaker Gaps in the Broad Autism Phenotype.Psychophysiology · 2026Article
- Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm.Translational psychiatry · 2026Article
- Discourse Marker Use in Mothers of Autistic Individuals and FMR1 Premutation Carriers.Journal of autism and developmental disorders · 2026Article
- Semantic and Syntactic Language Differences Associated with theJournal of neurolinguistics · 2026Article
- The impact of individual factors on linguistic alignment of autistic boys and their mothers.Autism : the international journal of research and practice · 2026Article
- Gaze-Speech Coordination During Narration in Autism Spectrum Disorder and First-Degree Relatives.Brain sciences · 2026Article
- Cognitive-behavioral phenotypes inFrontiers in molecular neuroscience · 2026Article
- Narrative and visual attention in autism spectrum disorder: a cross-cultural perspective.Frontiers in psychiatry · 2026Article
- Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025Article
- Pre-trained artificial intelligence language model represents pragmatic language variability central to autism and genetically related phenotypes.Autism : the international journal of research and practice · 2025Article
- Prosodic Differences in Women with theInternational journal of molecular sciences · 2025Article
- Language use predicts symptoms of fragile X-associated tremor/ataxia syndrome in men and women with the FMR1 premutation.Scientific reports · 2024Article
- Social Communication Delay in an Unbiased Sample of Preschoolers With theJournal of speech, language, and hearing research : JSLHR · 2024Article
- Autistic Traits Associated with the Fragile X Premutation Allele: The Neurodevelopmental Profile.Developmental neuropsychology · 2024Review
- Review
- Differences in speech articulatory timing and associations with pragmatic language ability in autism.Research in autism spectrum disorders · 2023Article
- A longitudinal investigation of pragmatic language across contexts in autism and related neurodevelopmental conditions.Frontiers in neurology · 2023Article
- Detecting autism from picture book narratives using deep neural utterance embeddings.International journal of language & communication disorders · 2022Article
- Autism spectrum disorder in the fragile X premutation state: possible mechanisms and implications.Journal of neurology · 2022Review
- Verbal entrainment in autism spectrum disorder and first-degree relatives.Scientific reports · 2022Article
7 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
Substantial phenotypic overlap exists between fragile X syndrome (FXS) and autism, suggesting that FMR1 (the gene causing FXS) poses a significant risk for autism. Cross-population comparisons of FXS and autism therefore offer a potentially valuable method for refining the range of phenotypes associated with variation in FMR1. This study adopted a broader phenotype approach, focusing on parents who are at increased genetic liability for autism or FXS. Women who were carriers of FMR1 in its premutation state were compared with mothers of individuals with autism, and controls in an attempt to determine whether subtle features of the broad autism phenotype may express at elevated rates among FMR1 premutation carriers. The principal personality and language features comprising the broad autism phenotype (i.e., rigid and aloof personality, and particular patterns of pragmatic language use) were assessed among 49 premutation carriers who were mothers of individuals with FXS, 89 mothers of individuals with autism, and 23 mothers of typically developing individuals. Relative to controls, the autism and premutation parent groups showed elevated rates of certain personality and language characteristics of the broad autism phenotype. Findings suggest partially overlapping personality and language profiles among autism and premutation parent groups, with rigid personality style and patterns of pragmatic language use emerging as features most clearly shared between groups. These results provide further evidence for the overlap of autism and FXS, and may implicate FMR1 in some of the subtle features comprising the broad autism phenotype.
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