ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Association between Post-Traumatic Stress Disorder, 5HTTLPR, and the Role of Ethnicity: A Meta-Analysis.Genes · 2024Pooled it
- Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder.Scientific reports · 2017Pooled it
- Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.Journal of affective disorders · 2015Pooled it
- Pooled it
- Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF.Brain sciences · 2026Article
- Review
- Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats.Scientific reports · 2020Article
- Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders.Frontiers in behavioral neuroscience · 2020Review
- Impact of Polymorphisms in the Serotonin Transporter Gene on Oscillatory Dynamics during Inhibition of Planned Movement in Children.Brain sciences · 2019Article
- Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization.Molecular neurobiology · 2019Review
- Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes.Behavioral neuroscience · 2018Article
- A Clinician's Guide to PTSD Biomarkers and Their Potential Future Use.Focus (American Psychiatric Publishing) · 2018Review
- Evaluation of 5-HTTLPR Gene Polymorphism and Resilience Components on the Development of Psychopathology in Adolescent Sexual Abuse Cases.Noro psikiyatri arsivi · 2017Article
- PTSD, alcohol dependence, and conduct problems: Distinct pathways via lability and disinhibition.Addictive behaviors · 2017Article
- Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Epigenetic marks as the link between environment and development: examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene.Brain and behavior · 2016Article
- RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Stress and Fear Extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.Annual review of psychology · 2016Review
- Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.Psychiatry research · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
We reported that the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) moderates the effect of childhood adversity on posttraumatic stress disorder (PTSD) risk [Xie et al. (2009); Arch Gen Psychiatry 66 (11): 1201-1209]. In the present study, we considered 5,178 subjects (a group with generally high substance dependence comorbidity, as for our previous study) using similar methodology to replicate our previous results. We used logistic regression analyses to explore the interaction effect of 5-HTTLPR genotype and childhood adversity on PTSD risk. We found that, as reported in our previous study, in individuals with childhood adversity, the presence of one or two copies of the S allele of 5-HTTLPR increased the risk to develop PTSD. This gene-environment interaction effect was present in European Americans (EAs), but not in African Americans (AAs; EAs, OR = 1.49, 95% CI = 1.07-2.08, P = 0.019; AAs, OR = 0.90, 95% CI = 0.60-1.35, P = 0.62). The statistical power to detect this interaction effect was increased when data were combined with those from our previous study [Xie et al. (2009); Arch Gen Psychiatry 66 (11): 1201-1209]. The findings reported here replicate those from our previous work, adding to a growing body of research demonstrating that the 5-HTTLPR genotype moderates risk for anxiety and depression phenotypes in the context of stress and adverse events.
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