ArticleCytoskeleton (Hoboken, N.J.)2012
Neurofilaments are flexible polymers that often fold and unfold, but they move in a fully extended configuration.
Article in Cytoskeleton (Hoboken, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Gαi2 promotes microtubule-driven incorporation of neurofilaments to stabilise nascent axons in vivo.EMBO reports · 2026Article
- Article
- Axonal neurofilaments exhibit frequent and complex folding behaviors.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Live-cell imaging of neurofilament transport in cultured neurons.Methods in cell biology · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Time-lapse imaging of neurofilaments in axons of cultured nerve cells has demonstrated that these cytoskeletal polymers move along microtubule tracks in both anterograde and retrograde directions, powered by microtubule motors. The filaments exhibit short bouts of rapid intermittent movement interrupted by prolonged pauses, and the average velocity is slow because they spend most of their time pausing. Here, we show that axonal neurofilaments are also very flexible and frequently exhibit complex and dynamic folding and unfolding behaviors while they are pausing. Remarkably, however, when the filaments move in a sustained manner, we find that they always adopt an unfolded, that is, fully extended configuration, and this applies to movement in both anterograde and retrograde directions. Given the flexibility of neurofilament polymers and the apparent ease with which they can fold back on themselves, the fact that they move in a fully extended configuration suggests that moving neurofilaments may be pulled from their leading end. Thus, we speculate that motors may bind to the leading ends of neurofilaments polymers during both anterograde and retrograde motion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.