ReviewBirth defects research. Part C, Embryo today : reviews2012
Computational models for mechanics of morphogenesis.
Review in Birth defects research. Part C, Embryo today : reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 93 citations in OpenAlex.
- Optogenetic Rescue Reveals Spatiotemporal Rules of Germ-Layer Patterning.bioRxiv : the preprint server for biology · 2025Article
- Linel2D-Net: A deep learning approach to solving 2D linear elastic boundary value problems on image domains.iScience · 2024Article
- Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems.Mechanobiology in medicine · 2024Article
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Collective behavior and self-organization in neural rosette morphogenesis.Frontiers in cell and developmental biology · 2023Review
- Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis.Proceedings. Biological sciences · 2022Article
- Assessing Early Cardiac Outflow Tract Adaptive Responses Through Combined Experimental-Computational Manipulations.Annals of biomedical engineering · 2021Article
- Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation.Scientific reports · 2021Article
- Tools to reverse-engineer multicellular systems: case studies using the fruit fly.Journal of biological engineering · 2019Review
- An Observation Data Driven Simulation and Analysis Framework for Early Stage C. elegans Embryogenesis.Journal of biomedical science and engineering · 2018Article
- Post-Turing tissue pattern formation: Advent of mechanochemistry.PLoS computational biology · 2018Article
- Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis.Journal of visualized experiments : JoVE · 2018Article
- Role of the boundary in feather bud formation on one-dimensional bioengineered skin.APL bioengineering · 2018Article
- Apoptosis generates mechanical forces that close the lens vesicle in the chick embryo.Physical biology · 2018Article
- A Preferred Curvature-Based Continuum Mechanics Framework for Modeling Embryogenesis.Biophysical journal · 2018Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Demystification of animal symmetry: symmetry is a response to mechanical forces.Biology direct · 2017Article
- Article
- Naturally Engineered Maturation of Cardiomyocytes.Frontiers in cell and developmental biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In the developing embryo, tissues differentiate, deform, and move in an orchestrated manner to generate various biological shapes driven by the complex interplay between genetic, epigenetic, and environmental factors. Mechanics plays a key role in regulating and controlling morphogenesis, and quantitative models help us understand how various mechanical forces combine to shape the embryo. Models allow for the quantitative, unbiased testing of physical mechanisms, and when used appropriately, can motivate new experimentaldirections. This knowledge benefits biomedical researchers who aim to prevent and treat congenital malformations, as well as engineers working to create replacement tissues in the laboratory. In this review, we first give an overview of fundamental mechanical theories for morphogenesis, and then focus on models for specific processes, including pattern formation, gastrulation, neurulation, organogenesis, and wound healing. The role of mechanical feedback in development is also discussed. Finally, some perspectives aregiven on the emerging challenges in morphomechanics and mechanobiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.