Evidence map›Paper›PMID 22692830›Full record

ArticleJournal of the American Society for Mass Spectrometry2012

HDX workbench: software for the analysis of H/D exchange MS data.

Bruce D Pascal, Scooter Willis, Janelle L Lauer, Rachelle R Landgraf, Graham M West, David Marciano, Scott Novick, Devrishi Goswami, Michael J Chalmers, Patrick R Griffin

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. HXMS: a standardized file format for HX-MS data.Bioinformatics (Oxford, England) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. HXMS: a standardized file format for HX/MS data.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. A framework for automated multimodal HDX-MS analysis.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Article

138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bruce D PascalDepartment of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.
Scooter Willis
Janelle L Lauer
Rachelle R Landgraf
Graham M West
David Marciano
Scott Novick
Devrishi Goswami
Michael J Chalmers
Patrick R Griffin

Funding

Development of H/D exchange technology for the study of large protein complexesR01GM084041 · NIGMS · SCRIPPS FLORIDA · PI GRIFFIN, PATRICK ROBERT · 2009 to 2012
$1.6M
Acquisition of a LTQ/Orbitrap MS to advance the study of protein dynamicsS10RR027270 · NCRR · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, PATRICK ROBERT · 2010 to 2010
$500k
NCRR NIH HHS S10 RR027270NIGMS NIH HHS R01 GM084041NIGMS NIH HHS R01-GM084041
6 · The paper itself

Abstract

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu .

Indexed as

SoftwareAlgorithmsAmino Acid SequenceDeuterium Exchange MeasurementMolecular Sequence DataPeptidesProteinsReproducibility of ResultsSequence AlignmentSequence Analysis, ProteinTandem Mass SpectrometryUser-Computer InterfacePeptidesProteins

Identifiers

PMID22692830
PMCPMC3808162

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.