ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Epigenetic mechanisms in learned fear: implications for PTSD.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
79 citing papers in PubMed, 186 citations in OpenAlex.
- Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.iScience · 2026Article
- Mild traumatic brain injury increases vulnerability to post-traumatic stress disorder in rats and the possible role of hippocampal DNA methylation.Frontiers in behavioral neuroscience · 2025Article
- Ameliorating Effect of FermentedNutrients · 2024Article
- Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction.Psychopharmacology · 2024Article
- Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice.Neuroscience bulletin · 2023Article
- Seizure susceptibility to various convulsant stimuli in the BTBR mouse model of autism spectrum disorders.Frontiers in pharmacology · 2023Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- An epigenetic mechanism for over-consolidation of fear memories.Molecular psychiatry · 2022Article
- Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice.Brain pathology (Zurich, Switzerland) · 2022Article
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- An allostatic epigenetic memory on chromatin footprints after double-hit acute stress.Neurobiology of stress · 2022Article
- Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD.Translational psychiatry · 2022Article
- Addressing the biological embedding of early life adversities (ELA) among adults through mindfulness: Proposed mechanisms and review of converging evidence.Neuroscience and biobehavioral reviews · 2022Review
- Epigenetic Approach to PTSD: In the Aspects of Rat Models.Global medical genetics · 2022Review
- Association of DNA methylation with energy and fear-related behaviors in canines.Frontiers in psychology · 2022Article
- Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice.Scientific reports · 2021Article
- Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety.Physiological reports · 2021Article
- Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain.Annual review of pharmacology and toxicology · 2021Review
- A gene expression atlas for different kinds of stress in the mouse brain.Scientific data · 2020Article
- Metabolic and Cognitive Effects of Ranolazine in Type 2 Diabetes Mellitus: Data from an in vivo Model.Nutrients · 2020Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
One of the most exciting discoveries in the learning and memory field in the past two decades is the observation that active regulation of gene expression is necessary for experience to trigger lasting functional and behavioral change, in a wide variety of species, including humans. Thus, as opposed to the traditional view of 'nature' (genes) being separate from 'nurture' (environment and experience), it is now clear that experience actively drives alterations in central nervous system (CNS) gene expression in an ongoing fashion, and that the resulting transcriptional changes are necessary for experience to trigger altered long-term behavior. In parallel over the past decade, epigenetic mechanisms, including regulation of chromatin structure and DNA methylation, have been shown to be potent regulators of gene transcription in the CNS. In this review, we describe data supporting the hypothesis that epigenetic molecular mechanisms, especially DNA methylation and demethylation, drive long-term behavioral change through active regulation of gene transcription in the CNS. Specifically, we propose that epigenetic molecular mechanisms underlie the formation and stabilization of context- and cue-triggered fear conditioning based in the hippocampus and amygdala, a conclusion reached in a wide variety of studies using laboratory animals. Given the relevance of cued and contextual fear conditioning to post-traumatic stress, by extension we propose that these mechanisms may contribute to post-traumatic stress disorder (PTSD) in humans. Moreover, we speculate that epigenetically based pharmacotherapy may provide a new avenue of drug treatment for PTSD-related cognitive and behavioral function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.