Evidence map›Paper›PMID 22692022›Full record

ArticleEuropean journal of clinical nutrition2012

The effect of vitamin D and frailty on mortality among non-institutionalized US older adults.

E Smit, C J Crespo, Y Michael, F A Ramirez-Marrero, G R Brodowicz, S Bartlett, R E Andersen

Abstract read
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In one paragraph

Article in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. The Role of Inflammatory and Cytokine Biomarkers in the Pathogenesis of Frailty Syndrome.Endocrine, metabolic & immune disorders drug targets · 2022
    Review
  8. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

E SmitDepartment of Public Health, Oregon State University, Corvallis, OR 97331, USA. Ellen.Smit@oregonstate.edu
C J Crespo
Y Michael
F A Ramirez-Marrero
G R Brodowicz
S Bartlett
R E Andersen

Funding

Portland Bridges to Baccalaureate ProgramR25GM086349 · NIGMS · PORTLAND STATE UNIVERSITY · PI CRESPO, CARLOS J. · 2008 to 2012
$967k
NIGMS NIH HHS 1 R25 GM086349-01
6 · The paper itself

Abstract

BACKGROUND/

objectivesAlthough both frailty and low vitamin D have been separately associated with an increased risk for adverse health, their joined effects on mortality have not been reported. The current study examined prospectively the effects of frailty and vitamin D status on mortality in US older adults. SUBJECTS/

methodsParticipants aged ≥ 60 years in The Third National Health and Nutrition Examination Survey with 12 years of mortality follow-up were included in the analysis (n=4731). Frailty was defined as meeting three or more criteria and pre-frailty as meeting one or two of the five frailty criteria (low body mass index (BMI), slow walking, weakness, exhaustion and low physical activity). Vitamin D status was assessed by serum 25-hydroxyvitamin D (25(OH)D) and categorized into quartiles. Analyses were adjusted for gender, race, age, smoking, education, latitude and other comorbid conditions.

resultsSerum 25(OH)D concentrations were lowest in participants with frailty, intermediate in participants with pre-frailty and highest in participants without frailty. The odds of frailty in the lowest quartile of serum 25(OH)D was 1.94 times the odds in the highest quartile (95% confidence interval (CI): 1.09-3.44). Mortality was positively associated with frailty, with the risk among participants who were frail and had low serum 25(OH)D being significantly higher than those who were not frail and who had high concentrations of serum 25(OH)D (hazards ratio 2.98; 95% CI: 2.01-4.42).

conclusionOur results suggest that low serum 25(OH)D is associated with frailty, and there is additive joint effects of serum 25(OH)D and frailty on all-cause mortality in older adults.

Indexed as

MortalityAgedAged, 80 and overAge FactorsCohort StudiesFemaleFrail ElderlyHumansLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisNutrition SurveysRegression AnalysisUnited StatesVitamin D25-hydroxyvitamin DVitamin D

Identifiers

PMID22692022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.