Evidence map›Paper›PMID 22691958›Full record

ArticleTransplantation2012

Depression diagnoses after living kidney donation: linking U.S. Registry data and administrative claims.

Krista L Lentine, Mark A Schnitzler, Huiling Xiao, David Axelrod, Connie L Davis, Melanie McCabe, Daniel C Brennan, Sheila Leander, Amit X Garg, Amy D Waterman

Abstract read
In one paragraph

Article in Transplantation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Assessing Early Supportive Care Needs among Son or Daughter Haploidentical Transplantation Donors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
  11. Article
  12. Article
  13. Antidepressant medication use before and after kidney transplant: implications for outcomes - a retrospective study.Transplant international : official journal of the European Society for Organ Transplantation · 2018
    Article
  14. Validation of Living Donor Nephrectomy Codes.Canadian journal of kidney health and disease · 2018
    Article
  15. The National Landscape of Living Kidney Donor Follow-Up in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  16. Review
  17. Predonation Prescription Opioid Use: A Novel Risk Factor for Readmission After Living Kidney Donation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  18. Uterus transplantation: current progress and future prospects.International journal of women's health · 2016
    Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Krista L LentineSaint Louis University Center for Outcomes Research, 3545 Lafayette Ave., St. Louis, MO 63104, USA. lentinek@slu.edu
Mark A Schnitzler
Huiling Xiao
David Axelrod
Connie L Davis
Melanie McCabe
Daniel C Brennan
Sheila Leander
Amit X Garg
Amy D Waterman
Saint Louis University · USWashington University in St. Louis · USDartmouth–Hitchcock Medical Center · USWestern University · CA

Funding

Washington University Center for Kidney Disease ResearchP30DK079333 · NIDDK · WASHINGTON UNIVERSITY · PI HAMMERMAN, MARC RANDALL · 2007 to 2011
$5.1M
Cardiovascular Risk Prediction after Kidney TransplantK08DK073036 · NIDDK · SAINT LOUIS UNIVERSITY · PI LENTINE, KRISTA L · 2006 to 2010
$668k
NIDDK NIH HHS K08 DK073036NIDDK NIH HHS K08DK073036NIDDK NIH HHS P30 DK079333NIDDK NIH HHS P30DK079333
6 · The paper itself

Abstract

backgroundLimited data exist on correlates of psychological outcomes after kidney donation.

methodsWe used a database integrating Organ Procurement and Transplantation Network registrations for 4650 living kidney donors from 1987 to 2007 with administrative data of a U.S. private health insurer (2000-2007 claims) to identify depression diagnoses among prior living donors. The burden and demographic correlates of depression after enrollment in the insurance plan were estimated by Cox regression. Graft failure and death of the donor's recipient were examined as time-varying exposures.

resultsAfter start of insurance benefits, the cumulative frequency of depression diagnosis was 4.2% at 1 year and 11.5% at 5 years, and depression among donors was less common than among age- and gender-matched general insurance beneficiaries (rate ratio, 0.70; 95% confidence intervals [CI], 0.60-0.81). Demographic and clinical correlates of increased likelihood of depression diagnoses among the prior donors included female gender, white race, and some perioperative complications. After adjustment for donor demographic factors, recipient death (adjusted hazard ratio (aHR), 2.23; 95% CI, 1.11-4.48) and death-censored graft failure (aHR, 3.30; 95% CI, 1.49-7.34) were associated with two to three times the relative risk of subsequent depression diagnosis among nonspousal unrelated donors. There were trends toward increased depression diagnoses after recipient death and graft failure among spousal donors but no evidence of associations of these recipient events with the likelihood of depression diagnosis among related donors.

conclusionsRecipient death and graft loss predict increased depression risk among unrelated living donors in this privately insured sample. Informed consent and postdonation care should consider the potential impact of recipient outcomes on the psychological health of the donor.

Indexed as

Kidney TransplantationRegistriesAdultDepressionFemaleHumansInsurance, HealthLiving DonorsMaleMiddle AgedProportional Hazards ModelsReoperationUnited States

Identifiers

PMID22691958
PMCPMC4447542
OpenAlexW2062782327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.