ArticleActa crystallographica. Section F, Structural biology and crystallization communications2012
Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein.
Article in Acta crystallographica. Section F, Structural biology and crystallization communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Adhirons are efficient tools to guide antiviral ligand discovery.Communications biology · 2025Article
- Development of a multiplex assay for antibody detection in serum against pathogens affecting ruminants.Transboundary and emerging diseases · 2021Article
- Development of a multiplex microsphere immunoassay for the detection of antibodies against highly pathogenic viruses in human and animal serum samples.PLoS neglected tropical diseases · 2020Article
- Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.PLoS neglected tropical diseases · 2020Article
- Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTagged Nucleoprotein for Potential Application in DiagnosisIranian biomedical journal · 2019Article
- The crystal structure of the Hazara virus nucleocapsid protein.BMC structural biology · 2015Article
- Genomic Characterization of Yogue, Kasokero, Issyk-Kul, Keterah, Gossas, and Thiafora Viruses: Nairoviruses Naturally Infecting Bats, Shrews, and Ticks.The American journal of tropical medicine and hygiene · 2015Article
- Structure of Crimean-Congo hemorrhagic fever virus nucleoprotein: superhelical homo-oligomers and the role of caspase-3 cleavage.Journal of virology · 2012Article
- Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein.Journal of virology · 2012Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crimean-Congo haemorrhagic fever virus (CCHFV) is a member of the Nairovirus genus within the Bunyaviridae family of segmented negative-sense RNA viruses. This paper describes the expression, purification and crystallization of full-length CCHFV nucleocapsid (N) protein and the collection of a 2.1 Å resolution X-ray diffraction data set using synchrotron radiation. Crystals of the CCHFV N protein belonged to space group C2, with unit-cell parameters a = 150.38, b = 72.06, c = 101.23 Å, β = 110.70° and two molecules in the asymmetric unit. Circular-dichroism analysis provided insight into the secondary structure, whilst gel-filtration analysis revealed possible oligomeric states of the N protein. Structural determination is ongoing.
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