ArticleBehavioral and brain functions : BBF2012
A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs.
Article in Behavioral and brain functions : BBF, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Neurospecific Molecules Measured in Periphery in Humans: How Do They Correlate with the Brain Levels? A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity.European child & adolescent psychiatry · 2018Article
- The Dopamine Receptor D4 Gene (Frontiers in behavioral neuroscience · 2018Article
- Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.Epigenetics · 2018Article
- DNA methylation as a predictor of fetal alcohol spectrum disorder.Clinical epigenetics · 2018Article
- Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.Frontiers in genetics · 2018Article
- Epigenetic regulation of the DRD4 gene and dimensions of attention-deficit/hyperactivity disorder in children.European child & adolescent psychiatry · 2016Article
- Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases.Briefings in bioinformatics · 2016Article
- A decade of contributions to understanding and ameliorating attention deficit-hyperactivity disorder.Behavioral and brain functions : BBF · 2016Review
- PANDAS and comorbid Kleine-Levin syndrome.Journal of child and adolescent psychopharmacology · 2015Article
- Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults.Psychopharmacology · 2014Article
- Male-specific association between dopamine receptor D4 gene methylation and schizophrenia.PloS one · 2014Article
- Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search.Social psychiatry and psychiatric epidemiology · 2014Article
- Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females.PloS one · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDopamine receptor D4(DRD4) polymorphisms have been associated with a number of psychiatric disorders, but little is known about the mechanism of these associations. DNA methylation is linked to the regulation of gene expression and plays a vital role in normal cellular function, with abnormal DNA methylation patterns implicated in a range of disorders. Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome.
methodsTo investigate the potential influence of cis-acting genetic elements within DRD4, we analysed DRD4 promoter DNA methylation levels in the transformed lymphoblastoid cell-line DNA of 89 individuals (from 30 family-trios). Five SNPs located +/- 10kb of the promoter region were interrogated for associations with DNA methylation levels.
resultsFour significant SNP associations were found with DNA methylation (rs3758653, rs752306, rs11246228 and rs936465). The associations of rs3758653 and rs936465 with DNA methylation were tested and nominally replicated (p-value < 0.05) in post-mortem brain tissue from an independent sample (N = 18). Interestingly, the DNA methylation patterns observed in post-mortem brain tissue were similar to those observed in transformed lymphoblastoid cell line DNA.
conclusionsThe link reported between DNA sequence and DNA methylation offers a possible functional role to seemingly non-functional SNP associations. DRD4 has been implicated in several psychiatric disease phenotypes and our results shed light upon the possible mode of action of SNP associations in this region.
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