Evidence map›Paper›PMID 22691604›Full record

ArticleHerpesviridae2012

Herpes simplex virus and varicella zoster virus, the house guests who never leave.

Paul R Kinchington, Anthony J St Leger, Jean-Marc G Guedon, Robert L Hendricks

Open access · hybridAbstract read
In one paragraph

Article in Herpesviridae, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Cancer viroimmunotherapy platforms based on varicella-zoster virus and cytomegalovirus.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  4. Clinical development of therapeutic mRNA applications.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Herpes Zoster Risk in Patients with Rheumatoid Arthritis and Its Association with Medications Used.International journal of environmental research and public health · 2023
    Observational
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paul R KinchingtonDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Hendricksrr@upmc.edu.
Anthony J St Leger
Jean-Marc G Guedon
Robert L Hendricks
University of Pittsburgh · US

Funding

ROLE OF CYTOTOXIC LYMPHOCYTES IN HSV-1 CORNEAL LESIONSR01EY005945 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HENDRICKS, ROBERT L · 1986 to 2017
$8.3M
Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic NeuralgiaR01NS064022 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINCHINGTON, PAUL R. · 2009 to 2019
$3.6M
Interdisciplinary Visual Sciences (IVS) Traininig ProgramT32EY017271 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann, Paul R. Kinchington · 2008 to 2026
$3.6M
Gene Expression in HSV-1 Latency After Corneal InfectionR01EY015291 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINCHINGTON, PAUL R. · 2004 to 2013
$2.9M
NEI NIH HHS R01 EY005945NEI NIH HHS R01 EY015291NEI NIH HHS T32 EY017271NINDS NIH HHS R01 NS064022
6 · The paper itself

Abstract

Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the host. All three viruses have the potential to reactivate causing recurrent disease. Regardless of the homology between the different virus strains, the three viruses are characterized by varying pathologies. This review will highlight the differences in infection pattern, immune response, and pathogenesis associated with HSV-1 and VZV.

Identifiers

PMID22691604
PMCPMC3541251
OpenAlexW2168573843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.