ArticleInteractive cardiovascular and thoracic surgery2012
Negative-pressure wound therapy for deep sternal wound infections reduces the rate of surgical interventions for early re-infections.
Article in Interactive cardiovascular and thoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Pooled it
- Nationwide trends in incidence of deep sternal wound infection after cardiac surgery and its association with long-term mortality.Journal of cardiothoracic surgery · 2026Observational
- Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis.Journal of advanced research · 2026Article
- Negative-Pressure Induces Epithelial-Mesenchymal Transition via Thrombospondin-1 Upregulation in Intact Diabetic Skin.International wound journal · 2026Article
- Impact of delayed sternal closure and negative pressure therapy after complex cardiovascular surgery.Journal of cardiothoracic surgery · 2025Observational
- Clinical and Microbiology Predictors for Therapeutic Failure in Sternal Surgical Site Infections - A Retrospective Cohort Study.Arquivos brasileiros de cardiologia · 2025Article
- Antimicrobial hydrogel foam dressing with controlled release of gallium maltolate for infection control in chronic wounds.Bioactive materials · 2024Article
- RETRACTED: Effects of negative-pressure wound therapy in the prevention of surgical-site wound infection after vascular surgery: A meta-analysis.International wound journal · 2024Article
- The role of negative pressure wound therapy in the treatment of poststernotomy mediastinitis in Asians: A single-center, retrospective cohort study.Health science reports · 2023Article
- Macroporous latex biomembrane from Hancornia speciosa modulates the inflammatory process and has a debridement effect on wound healing in rats.Acta cirurgica brasileira · 2023Article
- Negative-Pressure Wound Therapy: What We Know and What We Need to Know.Advances in experimental medicine and biology · 2023Article
- The Modified Sternoplasty: A Novel Surgical Technique for Treating Mediastinitis.Plastic and reconstructive surgery. Global open · 2022Article
- The management of deep sternal wound infection: Literature review and reconstructive algorithm.JPRAS open · 2021Review
- Negative Pressure Wound Therapy (NPWT): Our Experience in Pakistan With Locally Made Dressing.Cureus · 2020Article
- Negative pressure wound therapy with instillation on sternal wound: is it really worrisome?Indian journal of thoracic and cardiovascular surgery · 2019Article
- Deep sternal wound infections: Evidence for prevention, treatment, and reconstructive surgery.Archives of plastic surgery · 2019Article
- Hospitalised patients' experiences during Negative Pressure Wound Therapy due to surgical site infection after vascular and cardiac surgery.International wound journal · 2018Article
- Deconstructing negative pressure wound therapy.International wound journal · 2017Review
- Early application of negative pressure wound therapy to acute wounds contaminated withExperimental and therapeutic medicine · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the outcome of treatment for deep sternal wound infection (DSWI) in a nationwide patient cohort, before and after the introduction of negative-pressure wound therapy (NPWT).
methodsThis was a population-based cohort of all patients treated for DSWI in Iceland out of 2446 open heart operations performed between 2000 and 2010. Length of hospital stay, survival and reoperations were compared in (i) 23 patients treated with open and/or closed irrigation before August 2005 (conventional treatment, CvT group) and in (ii) 20 patients treated after this time with NPWT as a first-line therapy (NPWT group).
resultsThe DSWI rate was 1.8% and did not change during the study period. Demographics were similar for both groups, except for peripheral arterial disease which was less common in the NPWT group. Coagulase-negative staphylococci were also more common (as the only pathogen identified) in the NPWT group (70% vs 30%, P = 0.01). The median length of hospital stay was 43 days in both groups and the sternum could be closed with delayed primary closure in all except 2 patients, one in each group. Eight patients in the CvT group required surgical revision for re-infections, including debridement and rewiring, when compared with 1 patient in the NPWT group (P = 0.02). Furthermore, 6 patients in the CvT group developed late chronic infections of the sternum requiring surgical revision, compared with one in the NPWT group (P = 0.10). The 30-day mortality was not significantly different between groups (4% vs 0%, P > 0.1) and the same was true for 1-year mortality (17% vs 0%, P = 0.11).
conclusionsNPWT significantly reduces the risk of early re-infections in patients with DSWI. There was a lower rate of late chronic sternal infections and lower mortality in the NPWT group, but the difference was not statistically significant. We conclude that NPWT should be considered as a first-line treatment for most DSWIs.
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