ArticleBMC microbiology2012
The distribution of plasmids that carry virulence and resistance genes in Staphylococcus aureus is lineage associated.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 161 citations in OpenAlex.
- Plasmids of co-circulating Staphylococcus aureus serve as vehicles for antimicrobial resistance sharing across diseased host-species at short timescales.BMC microbiology · 2026Article
- Plasmid diversity, antibiotic resistance and virulence genes associated with Staphylococcus aureus isolates from private hospitals in Gauteng, South Africa.World journal of microbiology & biotechnology · 2026Article
- Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution.Nature communications · 2026Article
- Characterisation of the wound microbiome and antimicrobial resistance profiles in clinical isolates from epidermolysis bullosa patients.Orphanet journal of rare diseases · 2026Article
- The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies.Infectious diseases and therapy · 2026Review
- Plasmidomic landscape of Staphylococcus aureus and the emergence of a CC5 subclade harboring the conjugative plasmid pSK41: implications for food safety and antimicrobial resistance.NPJ science of food · 2026Article
- Molecular characterization of mupirocin-resistant MRSA from Germany and South Africa.Frontiers in cellular and infection microbiology · 2026Article
- High colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.BMC microbiology · 2025Article
- Comparative genomics of endemicmSphere · 2025Article
- Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associatedMicrobiology spectrum · 2025Article
- Antimicrobial Resistance, Virulence Gene Profiling, and Spa Typing ofPathogens (Basel, Switzerland) · 2025Article
- Characterization of Staphylococcus argenteus in Christchurch, New Zealand, and comparison to global strains.Access microbiology · 2025Article
- Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing.Exploration (Beijing, China) · 2024Article
- Genomic Characterization of Methicillin-Resistant and Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2024Article
- Genetic Characterization of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Average nucleotide identity-basedmSystems · 2024Article
- Global genetic diversity and Asian clades evolution: a phylogeographic study ofAntimicrobial agents and chemotherapy · 2024Article
- Average Nucleotide Identity basedbioRxiv : the preprint server for biology · 2024Article
- Article
- Investigating genomic diversity ofFrontiers in microbiology · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus is major human and animal pathogen. Plasmids often carry resistance genes and virulence genes that can disseminate through S. aureus populations by horizontal gene transfer (HGT) mechanisms. Sequences of S. aureus plasmids in the public domain and data from multi-strain microarrays were analysed to investigate (i) the distribution of resistance genes and virulence genes on S. aureus plasmids, and (ii) the distribution of plasmids between S. aureus lineages.
resultsA total of 21 plasmid rep gene families, of which 13 were novel to this study, were characterised using a previously proposed classification system. 243 sequenced plasmids were assigned to 39 plasmid groups that each possessed a unique combination of rep genes. We show some resistance genes (including ermC and cat) and virulence genes (including entA, entG, entJ, entP) were associated with specific plasmid groups suggesting there are genetic pressures preventing recombination of these genes into novel plasmid groups. Whole genome microarray analysis revealed that plasmid rep, resistance and virulence genes were associated with S. aureus lineages, suggesting restriction-modification (RM) barriers to HGT of plasmids between strains exist. Conjugation transfer (tra) complex genes were rare.
conclusionThis study argues that genetic pressures are restraining the spread of resistance and virulence genes amongst S. aureus plasmids, and amongst S. aureus populations, delaying the emergence of fully virulent and resistant strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.