ArticleDiabetes technology & therapeutics2012
In vivo glucose monitoring using dual-wavelength polarimetry to overcome corneal birefringence in the presence of motion.
Article in Diabetes technology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Birefringence of the Human Cornea: A Review.Vision (Basel, Switzerland) · 2025Review
- High-precision non-invasive RBC and HGB detection system based on spectral analysis.Analytical and bioanalytical chemistry · 2023Article
- High-precision non-invasive RBC and HGB detection system based on spectral analysis.Analytical and bioanalytical chemistry · 2023Article
- Noninvasive Glucose Sensing In Vivo.Sensors (Basel, Switzerland) · 2023Review
- A new generation of sensors for non-invasive blood glucose monitoring.American journal of translational research · 2023Review
- Comparing the Rise in Glucose Concentration in Blood, Aqueous and Interstitial Fluid During a Glucose Tolerance Test.Translational vision science & technology · 2022Article
- Glucose-Sensing Photonic Nanochain Probes with Color Change in Seconds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Composite polarization systems for independent controlling polarization of two beams with different wavelengths.Biomedical optics express · 2021Article
- Article
- Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.PloS one · 2021Observational
- Non-Invasive Blood Glucose Monitoring Technology: A Review.Sensors (Basel, Switzerland) · 2020Review
- Review
- Broadband polarimetric glucose determination in protein containing media using characteristic optical rotatory dispersion.Biomedical optics express · 2019Article
- Real-time compensation method for robust polarimetric determination of glucose in turbid media.Biomedical optics express · 2019Article
- 2D Photonic Crystal Hydrogel Sensor for Tear Glucose Monitoring.ACS omega · 2018Article
- Corneal birefringence measured by spectrally resolved Mueller matrix ellipsometry and implications for non-invasive glucose monitoring.Biomedical optics express · 2016Article
- Italian contributions to the development of continuous glucose monitoring sensors for diabetes management.Sensors (Basel, Switzerland) · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveOver the past 35 years considerable research has been performed toward the investigation of noninvasive and minimally invasive glucose monitoring techniques. Optical polarimetry is one noninvasive technique that has shown promise as a means to ascertain blood glucose levels through measuring the glucose concentrations in the anterior chamber of the eye. However, one of the key limitations to the use of optical polarimetry as a means to noninvasively measure glucose levels is the presence of sample noise caused by motion-induced time-varying corneal birefringence. RESEARCH DESIGN AND
methodsIn this article our group presents, for the first time, results that show dual-wavelength polarimetry can be used to accurately detect glucose concentrations in the presence of motion-induced birefringence in vivo using New Zealand White rabbits.
resultsIn total, nine animal studies (three New Zealand White rabbits across three separate days) were conducted. Using the dual-wavelength optical polarimetric approach, in vivo, an overall mean average relative difference of 4.49% (11.66 mg/dL) was achieved with 100% Zone A+B hits on a Clarke error grid, including 100% falling in Zone A.
conclusionsThe results indicate that dual-wavelength polarimetry can effectively be used to significantly reduce the noise due to time-varying corneal birefringence in vivo, allowing the accurate measurement of glucose concentration in the aqueous humor of the eye and correlating that with blood glucose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.