ArticleAnnals of human biology2012
Inflammatory profiles in the non-pregnant state predict offspring birth weight at Cebu: evidence for inter-generational effects of low grade inflammation.
Article in Annals of human biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study.The Journal of pediatrics · 2018 · on this mapTrial
- Trial
- A Neurometabolic Pattern of Elevated Myo-Inositol in Children Who Are HIV-Exposed and Uninfected: A South African Birth Cohort Study.Frontiers in immunology · 2022Article
- The Impact of Early-Life Exposures on Women's Reproductive Health in Adulthood.Current epidemiology reports · 2021Review
- Maternal serum cytokine levels and risk of bipolar disorder.Brain, behavior, and immunity · 2017Article
- HIV-Exposed Uninfected Infants in Zimbabwe: Insights into Health Outcomes in the Pre-Antiretroviral Therapy Era.Frontiers in immunology · 2016Article
- Evolving ideas in primary care.Canadian family physician Medecin de famille canadien · 2015Article
- Contextualising complementary feeding in a broader framework for stunting prevention.Maternal & child nutrition · 2013Review
- C-reactive protein by pregnancy and lactational status among Filipino young adult women.American journal of human biology : the official journal of the Human Biology CouncilArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough maternal infection and inflammation during pregnancy can adversely affect offspring birth weight (BW), whether low grade inflammation in the non-pregnant state predicts BW is unknown.
aimTo evaluate relationships between offspring BW and pro- and anti-inflammatory factors measured in parous but non-pregnant women. SUBJECTS AND
methodsData come from 234 parous Filipino females (21.5 ± 0.3 years) in the Cebu Longitudinal Health and Nutrition Survey, a population-based birth cohort in Metropolitan Cebu, Philippines. Pro-inflammatory [Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), tumour necrosis factor alpha (TNFα), C-reactive protein (CRP)] and anti-inflammatory [Interleukin-10 (IL-10)] factors were measured in fasting plasma when the women were not pregnant, and related to recalled offspring BW.
resultsBW in female offspring was lower only among women with high IL-1β. Although pro-inflammatory cytokines did not predict BW in male offspring, women with higher anti-inflammatory IL-10 gave birth to larger males. Women with a combination of low inflammatory (IL-6) and high anti-inflammatory (IL-10) factors (interaction p < 0.104) gave birth to the largest males.
conclusionImmune factors measured outside of pregnancy predict offspring BW in these young women. Stable variation in inflammatory phenotype could impact the gestational environment of offspring, thus pointing to potential inter-generational effects of chronic low-grade inflammation.
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