ArticlePediatric reports2012
Muscle fat content and abdominal adipose tissue distribution investigated by magnetic resonance spectroscopy and imaging in obese children and youths.
Article in Pediatric reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Body weight and metabolic risk factors in patients with type 2 diabetes on a self-selected high-protein low-carbohydrate diet.European journal of nutrition · 2021Trial
- A carbohydrate-reduced high-protein diet improves HbADiabetologia · 2019Trial
- A randomized controlled trial on a multicomponent intervention for overweight school-aged children - Copenhagen, Denmark.BMC pediatrics · 2014Trial
- Noninvasive NMR/MRS Metabolic Parameters to Evaluate Metabolic Syndrome in Rats.Diagnostics (Basel, Switzerland) · 2022Article
- Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes.Frontiers in physiology · 2022Article
- The effects of muscle mass and muscle quality on cardio-metabolic risk in peripubertal girls: a longitudinal study from childhood to early adulthood.International journal of obesity (2005) · 2018Article
- Article
- Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents.World journal of gastroenterology · 2016Observational
- Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents.International journal of obesity (2005) · 2016Article
- Multidisciplinary care of obese children and adolescents for one year reduces ectopic fat content in liver and skeletal muscle.BMC pediatrics · 2015 · on this mapObservational
- 1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.PloS one · 2015Article
- The ethics of childhood obesity treatment - from the Childhood Obesity Task Force (COTF) of European Association for the Study of Obesity (EASO).Obesity facts · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The degree of fat deposition in muscle and its implications for obesity-related complications in children and youths are not well understood. One hundred and fifty-nine patients (mean age: 13.3 years; range: 6-20) with a body mass index (BMI) >90(th) percentile for age and sex were included. Muscle fat content (MFC) was measured in the psoas muscle by proton magnetic resonance spectroscopy. The patients were assigned to two groups: MFC <5% or ≥5%. Visceral adipose tissue volume (VAT) and subcutaneous adipose tissue volume (SAT) were measured by magnetic resonance imaging. The data were analysed to detect associations between MFC and BMI standard deviation scores, VAT and SAT, blood values, pubertal stages, and physical activity scores. The mean BMI standard deviation score (SDS) was 3.04 (range 1.32-5.02). The mean MFC was 8.9% (range 0.8-46.7), and 118 (74.2%) of 159 patients had an MFC ≥5%. Children with an MFC ≥5%, compared with children with an MFC <5%, had a higher BMI SDS (P=0.03), a higher VAT (P=0.04), and elevated intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) contents (both P<0.0001). SAT, SAT/VAT ratio, blood values, pubertal stages and physical activity scores did not differ between the two groups. Severely obese children and youths tend to have a high MFC, which is associated with elevated VAT, IMCL, and EMCL contents. An increased MFC may be associated with impaired metabolic processes, which may predispose these young people to obesity-related complications.
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