ArticleEvidence-based complementary and alternative medicine : eCAM2012
Interleukin-10 genotype correlated to deficiency syndrome in hepatitis B cirrhosis.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Differences of excess and deficiency zheng in patients with chronic hepatitis B by urinary metabonomics.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Clinical Applications of Omics Technologies on ZHENG Differentiation Research in Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
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Abstract
Traditional Chinese medicine (TCM) syndrome is an important basis for TCM diagnosis and treatment. As Child-Pugh classification as well as compensation and decompensation phase in liver cirrhosis, it is also an underlying clinical classification. In this paper, we investigated the correlation between single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) and TCM syndromes in patients with hepatitis B cirrhosis (HBC). Samples were obtained from 343 HBC patients in China. Three SNPs of IL-10 (-592A/C, -819C/T, and -1082A/G) were detected with polymerase chain-reaction-ligase detection reaction (PCR-LDR). The result showed the SNP-819C/T was significantly correlated with Deficiency syndrome (P = 0.031), but none of the 3 loci showed correlation either with Child-Pugh classification and phase in HBC patients. The logistic regression analysis showed that the Excess syndrome was associated with dizzy and spider nevus, and the Deficiency syndrome was associated with dry eyes, aversion to cold, IL-10-819C/T loci, and IL-10-1082A/G loci. The odds ratio (OR) value at IL-10-819C/T was 4.022. The research results suggested that IL-10-819C/T locus (TC plus CC genotype) is probably a risk factor in the occurrence of Deficiency syndrome in HBC patients.
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