ArticleMarine drugs2012
First total synthesis of a naturally occurring iodinated 5'-deoxyxylofuranosyl marine nucleoside.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Pyrimidine-containing natural products: occurrences and biological activities.Natural products and bioprospecting · 2026Review
- First Total Synthesis of 5'-Marine drugs · 2020Article
- Total Synthesis of Mycalisine B.Marine drugs · 2019Article
- An Expeditious Total Synthesis of 5'-Deoxy-toyocamycin and 5'-Deoxysangivamycin.Molecules (Basel, Switzerland) · 2019Article
- An Expedient Total Synthesis of Triciribine.Molecules (Basel, Switzerland) · 2017Article
- First total synthesis of kipukasin A.Beilstein journal of organic chemistry · 2017Article
- Concise total synthesis of two marine natural nucleosides: trachycladines A and B.Beilstein journal of organic chemistry · 2014Article
- Total synthesis of a marine alkaloid--rigidin E.Marine drugs · 2012Article
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Authors and funding
6 authors.
Funding
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Abstract
4-Amino-7-(5'-deoxy-β-D-xylofuranosyl)-5-iodo-pyrrolo[2,3-d]pyrimidine 1, an unusual naturally occurring marine nucleoside isolated from an ascidan, Diplosoma sp., was synthesized from D-xylose in seven steps with 28% overall yield on 10 g scale. The key step was Vorbrüggen glycosylation of 5-iodo-pyrrolo[2,3-d]pyrimidine with 5-deoxy-1,2-O-diacetyl-3-O-benzoyl-D-xylofuranose. Its absolute configuration was confirmed.
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