ArticleMarine drugs2012
Temporal trends in the secondary metabolite production of the sponge Aplysina aerophoba.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Diel transcriptional dynamics of a marine sponge and its microbiome in a natural environment.Animal microbiome · 2026Article
- Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals.Marine drugs · 2023Review
- Oceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges.Scientific reports · 2022Article
- Cytotoxic furanosesquiterpenoids and steroids fromPharmaceutical biology · 2021Article
- Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products.Marine drugs · 2021Article
- Integrated algal and oil palm biorefinery as a model system for bioenergy co-generation with bioproducts and biopharmaceuticals.Bioresources and bioprocessing · 2021Review
- Cytotoxic Compounds of Two Demosponges (Biomolecules · 2021Article
- Opisthobranch grazing results in mobilisation of spherulous cells and re-allocation of secondary metabolites in the sponge Aplysina aerophoba.Scientific reports · 2020Article
- Metabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Anti-Biofilm Effect of Biodegradable Coatings Based on Hemibastadin Derivative in Marine Environment.International journal of molecular sciences · 2017Article
- How Environmental Factors Affect the Production of Guanidine Alkaloids by the Mediterranean Sponge Crambe crambe.Marine drugs · 2017Article
- Article
- Who Produces Ianthelline? The Arctic Sponge Stryphnus fortis or its Sponge Epibiont Hexadella dedritifera: a Probable Case of Sponge-Sponge Contamination.Journal of chemical ecology · 2016Article
- Secondary Metabolome Variability and Inducible Chemical Defenses in the Mediterranean Sponge Aplysina cavernicola.Journal of chemical ecology · 2016Article
- Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.Marine drugs · 2015Review
- Will the Increasing of Anthropogenic Pressures Reduce the Biopotential Value of Sponges?Scientifica · 2015Article
- Sources of secondary metabolite variation in Dysidea avara (Porifera: Demospongiae): the importance of having good neighbors.Marine drugs · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporal changes in the production of secondary metabolites are far from being fully understood. Our study quantified, over a two-year period, the concentrations of brominated alkaloids in the ectosome and the choanosome of Aplysina aerophoba, and examined the temporal patterns of these natural products. Based on standard curves, we quantified the concentrations of aerophobin-2, aplysinamisin-1, and isofistularin-3: three of the four major peaks obtained through chemical profiling with high-performance liquid chromatography. Our results showed a striking variation in compound abundance between the outer and inner layers of the sponge. The ectosome showed high concentrations of bromocompounds during the summer months, while the choanosome followed no pattern. Additionally, we found that, from the outer layer of the sponge, aerophobin-2 and isofistularin-3 were significantly correlated with water temperature. The present study is one of the first to document quantitative seasonal variations in individual compounds over multiple years. Further studies will clarify the role of environmental, biological, and physiological factors in determining the seasonal patterns in the concentration of brominated alkaloids.
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