ArticleEpilepsy currents2012
Epileptogenesis: can the science of epigenetics give us answers?
Article in Epilepsy currents, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed.
- Commonalities in gene expression and methylation changes across two rat models of acquired epilepsy.Scientific reports · 2026Article
- Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy.Biomarker research · 2024Review
- The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.IBRO neuroscience reports · 2022Review
- A putative role for lncRNAs in epigenetic regulation of memory.Neurochemistry international · 2021Review
- Article
- DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.Clinical epigenetics · 2019Article
- Article
- Defects at the crossroads of GABAergic signaling in generalized genetic epilepsies.Epilepsy research · 2017Review
- Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of Epilepsy.Frontiers in neurology · 2017Article
- Dynamic DNA methylation regulates neuronal intrinsic membrane excitability.Science signaling · 2016Article
- The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine.Frontiers in molecular neuroscience · 2016Review
- Epigenetics and Epilepsy.Cold Spring Harbor perspectives in medicine · 2015Review
- Comorbidities in Neurology: Is adenosine the common link?Neuropharmacology · 2015Review
- Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy.Brain : a journal of neurology · 2015Article
- Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity.Neuropharmacology · 2014Review
- Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms.Frontiers in molecular neuroscience · 2014Review
- Epigenetics in the nervous system: An overview of its essential role.Indian journal of human genetics · 2013Review
- Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus.Neuroscience · 2013Article
- Folate and epigenetic mechanisms in neural tube development and defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?Frontiers in cellular neuroscience · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms are regulatory processes that control gene expression changes involved in multiple aspects of neuronal function, including central nervous system development, synaptic plasticity, and memory. Recent evidence indicates that dysregulation of epigenetic mechanisms occurs in several human epilepsy syndromes. Despite this discovery of a potential role for epigenetic mechanisms in epilepsy, few studies have fully explored their contribution to the process of epilepsy development known as epileptogenesis. The purpose of this article is to discuss recent findings suggesting that the process of epileptogenesis may alter the epigenetic landscape, affecting the gene expression patterns observed in epilepsy. Future studies focused on a better characterization of these aberrant epigenetic mechanisms hold the promise of revealing novel treatment options for the prevention and even the reversal of epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.