ArticleWorld journal of gastroenterology2012
Family history influences the early onset of hepatocellular carcinoma.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Early-Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites.Cancer science · 2026Review
- Association between family history and onset age of cancer in China.Chinese medical journal · 2026Article
- [Variational trend in disease characteristics of hepatitis B-related primary liver cancer populations in the past five years: a retrospective single-center cross-sectional study].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- Review
- Disparities in stage at diagnosis for liver cancer in China.Journal of the National Cancer Center · 2023Article
- Genetic Susceptibility to Hepatocellular Carcinoma in Patients with Chronic Hepatitis Virus Infection.Viruses · 2023Review
- Is early-onset cancer an emerging global epidemic? Current evidence and future implications.Nature reviews. Clinical oncology · 2022Review
- Reporting Liver Cancer Trends in the Island of Crete, Greece: Results from a Geo-Epidemiological Study.International journal of environmental research and public health · 2022Article
- Review
- Hepatitis B: Who should be treated?-managing patients with chronic hepatitis B during the immune-tolerant and immunoactive phases.World journal of gastroenterology · 2021Review
- Hepatocellular carcinoma in Senegal: epidemiological, clinical and etiological aspects about 229 cases atThe Pan African medical journal · 2021Article
- Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study.Viruses · 2019Article
- Familial association of lung cancer with liver cancer in first-degree relatives.Cancer management and research · 2019Article
- Familial hepatocellular carcinoma: 'A model for studying preventive and therapeutic measures'.Annals of medicine and surgery (2012) · 2018Review
- Gastrointestinal cancer risk in patients with a family history of gastrointestinal cancer.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2018Article
- Familial Hepatocellular Carcinoma- First Reported Case from India.Journal of clinical and diagnostic research : JCDR · 2016Article
- Comparison of the clinical characteristics and survival between Uyghur patients with hepatitis virus-related and non-B, non-C hepatocellular carcinoma in Xinjiang, China.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015Article
- Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China.International journal of clinical and experimental medicine · 2015Article
- Prevention of hepatocellular carcinoma in patients with chronic hepatitis B.World journal of gastrointestinal pharmacology and therapeutics · 2014Review
- Familial correlations of onset age of hepatocellular carcinoma: a population-based case-control family study.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients.
methodsWe studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.
resultsOf the 2242 patients, 165 (7.4%) had a positive family history of HCC and 2077 (92.6%) did not. The male to female ratio was 3.6:1, and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diagnosis in the positive- and negative-history groups were 52 years (range: 29-79 years) and 57 years (range: 18-89 years), respectively (P < 0.0001). Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%), whereas those out of 1577 patients with negative family history was 197 (12.5%), suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P = 0.0028).
conclusionMore intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.
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