ArticleJournal of natural science, biology, and medicine2012
Relationship between lipid and lipoprotein metabolism in trimesters of pregnancy in Nigerian women: Is pregnancy a risk factor?
Article in Journal of natural science, biology, and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of antenatal use of high energy nutritional supplements on cardio metabolic risk markers in underweight primi gravidas; a randomized controlled trial.BMC pregnancy and childbirth · 2024Trial
- Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study.BMC pregnancy and childbirth · 2017Trial
- Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus.Frontiers in endocrinology · 2025Article
- Are maternal serum subfatin levels altered in women with one abnormal glucose tolerance test value?Revista da Associacao Medica Brasileira (1992) · 2024Article
- Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices.Clinical medicine insights. Endocrinology and diabetes · 2022Article
- Triglyceride to HDL cholesterol ratio and risk for gestational diabetes and birth of a large-for-gestational-age newborn.Caspian journal of internal medicine · 2018Article
- Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.Oxidative medicine and cellular longevity · 2015Review
- Maternal Lipid Profile as a Risk Factor for Gestational Diabetes Mellitus in Obese Women.Current health sciences journalArticle
- Lipid Profile Pattern among Women Screened for Hyperglycaemia in Pregnancy at the University of Jos Teaching Hospital, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChanges in lipid metabolism have been shown to occur during pregnancy, to ensure a continuous supply of nutrients to the growing fetus, despite intermittent maternal food intake. Abnormal lipid metabolism has also been linked to atherosclerosis.
objectiveTo investigate the effect of pregnancy on the lipid profile and possible predisposition of pregnant Nigerian women to atherosclerosis. SETTINGS AND
designSerum lipid and lipoprotein levels of 60 apparently healthy pregnant women aged between 25 and 45 years, attending the antenatal clinic of the U.N.T.H, Enugu and 60 apparently healthy non-pregnant, age-matched females (controls) were estimated. The test samples were collected from each subject at each of the trimesters. MATERIALS AND
methodsTotal cholesterol (TC), high-density lipoprotein (HDL) and triglyceride (TG) were analyzed using enzymatic/spectrophotometric methods while low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were calculated using Friedewald's formula. STATISTICAL ANALYSIS USED: The data obtained were analyzed with Students' t-test and Pearson's Product Moment Correlation, using graph pad prism software program and results expressed as mean ± SD. The level of significance was determined at 95% confidence level. RESULTS AND
conclusionThe serum lipid levels were significantly higher (P<0.05) in all the trimesters of the pregnant women than in the controls. There was a steady increase in the serum lipid levels with increasing gestational age. A significant positive correlation (P<0.05) was observed between the lipid fractions and the different trimesters of pregnancy. TC/HDL was decreased significantly (P<0.05) in pregnant women, with increasing gestational age. Cardiac risk factor, however, decreased with gestational age, signifying possible protection from atherosclerosis. A comparison of two age groups of pregnant women (25-34 years and 35-45 years) showed no significant differences (P>0.05) in all the lipid fractions studied, suggesting no possible age-related effect on lipid metabolism in the women in their first trimester. Even with significant increase in plasma lipid during pregnancy, normal pregnancy in Nigerian women does not appear to increase the risk.
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