Trial reportThe Journal of clinical endocrinology and metabolism2012
Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program.
Trial report in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Endogenous sex hormones, metabolic syndrome, and diabetes in men and women.Current cardiology reports · 2014Pooled it
- The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32.Journal of the National Cancer Institute · 2021Trial
- Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program.BMJ open diabetes research & care · 2020Trial
- Prospective Randomized Biomarker Study of Metformin and Lifestyle Intervention for Prevention in Obese Women at Increased Risk for Endometrial Cancer.Cancer prevention research (Philadelphia, Pa.) · 2018Trial
- Changes in Visceral Adiposity, Subcutaneous Adiposity, and Sex Hormones in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2017Trial
- Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected].Obesity (Silver Spring, Md.) · 2015Trial
- Sex steroid levels and response to weight loss interventions among postmenopausal women in the diabetes prevention program.Obesity (Silver Spring, Md.) · 2014Trial
- The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program.Metabolism: clinical and experimental · 2013Trial
- Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program.The Journal of clinical endocrinology and metabolism · 2013Trial
- Reductions in glucose among postmenopausal women who use and do not use estrogen therapy.Menopause (New York, N.Y.) · 2013Trial
- Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.The Journal of clinical endocrinology and metabolism · 2012Trial
- Sex steroids and adiposity in a prospective observational cohort of youth.Obesity science & practice · 2021Article
- Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study.The Journal of clinical endocrinology and metabolism · 2019Observational
- The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes.Journal of the National Cancer Institute · 2018Article
- Response to Letter to the Editor: "Androgens, Irregular Menses, and Risk of Diabetes and Coronary Artery Calcification in the Diabetes Prevention Program".The Journal of clinical endocrinology and metabolism · 2018Article
- Endogenous sex steroid hormones and glucose in a South-Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South-Asians Living in America pilot study.Diabetic medicine : a journal of the British Diabetic Association · 2015Article
- Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?Menopause (New York, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
contextWhether endogenous sex hormones (ESH) [SHBG, estradiol, testosterone, and dehydroepiandrosterone (DHEA)] are altered by intensive lifestyle modification (ILS) or metformin and whether such changes affect glucose levels among dysglycemic postmenopausal women is unclear.
objectivesOur objective was to examine intervention impact on ESH and associations with fasting plasma glucose (FPG) and 2-h glucose changes among postmenopausal glucose-intolerant women.
designWe performed a secondary analysis of a randomized controlled trial.
participantsParticipants included postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n = 382) who participated in the Diabetes Prevention Program.
interventionsInterventions included ILS with the goals of weight reduction of at least 7% of initial weight and 150 min/wk of moderate intensity exercise or metformin or placebo administered 850 mg twice a day.
main outcome measuresIntervention-related changes in ESH and associations of changes in ESH and glucose levels were evaluated.
resultsILS significantly increased SHBG and decreased DHEA before and after adjustment for changes in waist circumference and fasting insulin. ILS did not alter estradiol or testosterone. Metformin did not change any ESH. ILS-induced increases in SHBG and declines in DHEA were associated with decreases in FPG and 2-h glucose, and declines in estradiol were associated with decreases in FPG, before and after adjustment for age, FSH, race/ethnicity, changes in waist circumference, and 1/fasting insulin.
conclusionsAmong postmenopausal glucose-intolerant women not using estrogen, ILS increased SHBG levels and lowered DHEA levels. These changes were associated with lower glucose independent of adiposity and insulin. Metformin effects upon ESH were not significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.