Evidence map›Paper›PMID 22689694›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2012

Poor sleep quality and sleep apnea are associated with higher resting energy expenditure in obese individuals with short sleep duration.

Lilian de Jonge, Xiongce Zhao, Megan S Mattingly, Samuel M Zuber, Paolo Piaggi, Gyorgy Csako, Giovanni Cizza, NIDDK Sleep Extension Study Group

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Resting energy expenditure and blood pressure: evidence of perpetual association.Journal of clinical hypertension (Greenwich, Conn.) · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lilian de JongeSection on Neuroendocrinology of Obesity, Diabetes, Endocrinology, and Obesity Branch/National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-2560, USA.
Xiongce Zhao
Megan S Mattingly
Samuel M Zuber
Paolo Piaggi
Gyorgy Csako
Giovanni Cizza
NIDDK Sleep Extension Study Group
National Institute of Diabetes and Digestive and Kidney Diseases · USAzienda Ospedaliera Universitaria Pisana · ITNational Institutes of Health Clinical Center · US

Funding

Chronic Sleep deprivation as a risk factor for endocrine and immune changesZIADK047054 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CIZZA, GIOVANNI · 2009 to 2013
$1.9M
Chronic sleep deprivation as a risk factor for metabolic syndrome and obesityZIADK075015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CIZZA, GIOVANNI · 2009 to 2013
$1.4M
Intramural NIH HHSNIDDK NIH HHS 06-DK-0036
6 · The paper itself

Abstract

contextEpidemiological studies reported an inverse or U-shaped relationship between sleep duration and weight. The relationship between sleep and resting energy expenditure (REE) has not been well characterized.

objectiveThe aim of the study was to determine the relationship between sleep, REE, and stress hormones. DESIGN AND

settingWe conducted a cross-sectional evaluation of a prospective cohort study at a tertiary referral research clinical center. SUBJECTS: Subjects included 126 obese individuals (30 males, 96 females; age, 40.5 ± 6.9 yr; body mass index, 38.6 ± 6.5 kg/m(2); sleep duration, 360 ± 50 min/night; and sleep efficiency, 79.5 ± 7.5%). MAIN OUTCOME MEASURE(S): REE and respiratory quotient (RQ) were assessed by indirect calorimetry. Sleep duration and sleep efficiency were assessed by actigraphy. Sleep quality was estimated by questionnaires, and sleep apnea was evaluated by respiratory disturbance index (RDI). Morning plasma ACTH, serum cortisol, and 24-h urinary free cortisol and catecholamines were also measured.

resultsRDI was positively correlated with REE adjusted by fat-free mass (r = 0.307; P = 0.003) and RQ (r = 0.377; P < 0.001). Sleep efficiency was inversely correlated with RQ (r = -0.200; P = 0.033). The relationship of RDI score and REE was stronger in men than women (P = 0.03). In women, serum cortisol was positively correlated (r = 0.407; P < 0.001), and Epworth sleepiness score tended to be inversely (r = -0.190; P = 0.086) correlated with adjusted REE. The RQ was positively related to RDI in women, whereas subjective sleep time was related to RQ in men. In a multiple regression model, RDI, serum cortisol, and urinary norepinephrine were directly related to REE, whereas serum cortisol also directly related to adjusted REE.

conclusionPoor sleep quality was associated with increased REE, a higher RQ indicating a shift from fat toward carbohydrate oxidation, and activation of the stress system.

Indexed as

Energy MetabolismAdultCohort StudiesCross-Sectional StudiesFemaleHumansLinear ModelsMaleMiddle AgedObesityProspective StudiesSleepSleep Apnea Syndromes

Identifiers

PMID22689694
PMCPMC3410277
OpenAlexW2129402932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.