Trial reportHaematologica2012
Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria.
Trial report in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Pharmacologic Inhibition of Erythrocyte Ferroportin Expression ExacerbatesMicroorganisms · 2025Article
- Research progress on the relationship betweenFrontiers in microbiology · 2025Review
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- The interleukin-10 family: Major regulators of the immune response againstSaudi journal of biological sciences · 2023Review
- Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.Malaria journal · 2023Article
- Article
- Hepcidin regulation in Kenyan children with severe malaria and non-typhoidalHaematologica · 2022Article
- How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children.International journal of molecular sciences · 2020Review
- Association between ActiveNutrients · 2019Article
- How Eliminating Malaria May Also Prevent Iron Deficiency in African Children.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Role of Activins in Hepcidin Regulation during Malaria.Infection and immunity · 2017Article
- Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia.Blood research · 2017Article
- Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia.Haematologica · 2017Article
- Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study.The American journal of tropical medicine and hygiene · 2016Article
- HIV-Associated Tuberculosis: Does the Iron-Regulatory Hormone Hepcidin Connect Anemia With Poor Prognosis?The Journal of infectious diseases · 2016Article
- Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.The Journal of clinical investigation · 2016Article
- Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.Malaria journal · 2015Article
- Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.EBioMedicine · 2015Article
- Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.PLoS neglected tropical diseases · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and different degrees of anemia. Hepcidin was increased on admission and fell significantly one week and one month after treatment. The association of hepcidin with hemoglobin was not linear and hepcidin was very low in severe malarial anemia. Parasite density, IL-10 and IL-6 were significantly associated with hepcidin concentration. Hepcidin response to acute malaria supports the notion of iron sequestration during acute malaria infection and suggests that iron administration during acute malaria is futile. These data suggest iron supplementation policies should take into account the high hepcidin levels and probable poor utilization of iron for up to one week after treatment for the majority of patients with acute malaria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.