ArticleAngewandte Chemie (International ed. in English)2012
Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors.
Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Mass Spectrometry Proteomics: A Key to Faster Drug Discovery.Journal of medicinal chemistry · 2026Review
- A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads.Chemical science · 2025Article
- Strategies for Competitive Activity-Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization.Israel journal of chemistry · 2023Article
- Rhodojaponin VI indirectly targets Cav2.2 channelsActa pharmaceutica Sinica. B · 2023Article
- A protocol to visualize on-target specific drug binding in mammalian tissue with cellular resolution using tissue clearing and click chemistry.STAR protocols · 2022Article
- Article
- Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Identification of a Bromodomain-like Region in 15-Lipoxygenase-1 Explains Its Nuclear Localization.Angewandte Chemie (International ed. in English) · 2021Article
- Article
- Activity-Based Protein Profiling (ABPP) of Oxidoreductases.Chembiochem : a European journal of chemical biology · 2021Review
- Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping.RSC chemical biology · 2020Article
- Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells.ACS central science · 2019Article
- An Affinity-Based Probe for the Human Adenosine AJournal of medicinal chemistry · 2018Article
- A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.Bioorganic & medicinal chemistry · 2017Article
- Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.Bioorganic & medicinal chemistry · 2017Article
- Activity-Based Probes for 15-Lipoxygenase-1.Angewandte Chemie (International ed. in English) · 2016Article
- Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction.Organic letters · 2016Article
- Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity.Chembiochem : a European journal of chemical biology · 2016Article
- Red emission fluorescent probes for visualization of monoamine oxidase in living cells.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High profile: new activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.
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Registered trials
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