ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Slits affect the timely migration of neural crest cells via Robo receptor.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Zebrafish sall1a and sall4 contribute to body elongation.Developmental biology · 2025Article
- Purkinje Neurons with Loss of STIM1 Exhibit Age-Dependent Changes in Gene Expression and Synaptic Components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deficits Associated With Loss of STIM1 in Purkinje Neurons Including Motor Coordination Can Be Rescued by Loss of Septin 7.Frontiers in cell and developmental biology · 2021Article
- Stage-dependent differential gene expression profiles of cranial neural crest-like cells derived from mouse-induced pluripotent stem cells.Medical molecular morphology · 2020Article
- Molecular Events Controlling Cessation of Trunk Neural Crest Migration and Onset of Differentiation.Frontiers in cell and developmental biology · 2020Article
- The origin and evolution of vertebrate neural crest cells.Open biology · 2020Review
- Review
- Screen for Slit/Robo signaling in trunk neural cells reveals new players.Gene expression patterns : GEP · 2018Article
- Moving in and Out: Dispersion of Cells in Self-Generated Gradients.Journal of clinical & cellular immunology · 2017Article
- Maximal Expression of the Evolutionarily Conserved Slit2 Gene Promoter Requires Sp1.Cellular and molecular neurobiology · 2016Article
- Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations.Oncotarget · 2016Article
- Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome.Human genetics · 2016Article
- Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia.Nature communications · 2016Article
- Oestrogen action and male fertility: experimental and clinical findings.Cellular and molecular life sciences : CMLS · 2015Review
- Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.Experimental neurology · 2015Article
- TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.Oncotarget · 2015Article
- Chicken trunk neural crest migration visualized with HNK1.Acta histochemica · 2015Article
- Slit molecules prevent entrance of trunk neural crest cells in developing gut.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2015Article
- Development of novel three-dimensional printed scaffolds for osteochondral regeneration.Tissue engineering. Part A · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeural crest cells emerge by delamination from the dorsal neural tube and give rise to various components of the peripheral nervous system in vertebrate embryos. These cells change from non-motile into highly motile cells migrating to distant areas before further differentiation. Mechanisms controlling delamination and subsequent migration of neural crest cells are not fully understood. Slit2, a chemorepellant for axonal guidance that repels and stimulates motility of trunk neural crest cells away from the gut has recently been suggested to be a tumor suppressor molecule. The goal of this study was to further investigate the role of Slit2 in trunk neural crest cell migration by constitutive expression in neural crest cells.
resultsWe found that Slit gain-of-function significantly impaired neural crest cell migration while Slit loss-of-function favored migration. In addition, we observed that the distribution of key cytoskeletal markers was disrupted in both gain and loss of function instances.
conclusionsThese findings suggest that Slit molecules might be involved in the processes that allow neural crest cells to begin migrating and transitioning to a mesenchymal type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.